115406-25-2

生物活性：R-75317 是一种特异性血小板活化因子 (FAP) 拮抗剂。R-75317 可防止肾小球肾炎大鼠模型 (通过注射从兔中提取的针对大鼠肾小球基底膜 (GBM) 抗原的抗体来诱导) 中肌酐清除率 (Ccr) 下降，并延迟蛋白尿出现以及改善肾小球肥大、系膜基质增生和间质纤维化。R-75317 可用于肾小球肾炎疾病的研究^[1]。

R-75317 is a specific platelet-activating factor (PAF) antagonist. R-75317 can prevent the decline in creatinine clearance (Ccr) in a rat model of glomerulonephritis induced by the injection of antibodies extracted from rabbits against rat glomerular basement membrane (GBM) antigens, delay the onset of proteinuria, and improve glomerular hypertrophy, mesangial matrix proliferation, and interstitial fibrosis. R-75317 may be useful in the study of glomerulonephritis^[1].