1. Immunology/Inflammation PI3K/Akt/mTOR Epigenetics NF-κB Metabolic Enzyme/Protease MAPK/ERK Pathway Apoptosis
  2. NOD-like Receptor (NLR) Interleukin Related AMPK Reactive Oxygen Species Toll-like Receptor (TLR) NF-κB JNK p38 MAPK Apoptosis
  3. 1572583-29-9

1572583-29-9

Teneligliptin hydrobromide hydrate Chemical Structure

Chemical Structure

1572583-29-9

  • Teneligliptin hydrobromide hydrate
  • Synonym(s): MP-513 hydrobromide hydrate ; 氢溴酸替格列汀水合物
  • CAS No.:1572583-29-9
  • Formula:C22H30N6OS
  • Molecular Weight:426.58

生物活性:Teneligliptin (MP-513) hydrobromide hydrate 是一种口服活性的和选择性的二肽基肽酶 4 (DPP-4) 抑制剂 (对人和大鼠酶的 IC50s 分别为 0.37 和 0.29 nM)。Teneligliptin hydrobromide hydrate 可改善血糖水平,可用于 2 型糖尿病相关的研究[1][2][3][4][5][6][7][8]

Teneligliptin (MP-513) hydrobromide hydrate is an orally active and selective dipeptidyl peptidase 4 (DPP-4) inhibitor (IC50s: 0.37 and 0.29 nM for the human and rat DPP-4, respectively). Teneligliptin hydrobromide hydrate improves blood glucose levels and can be used in researches related to type 2 diabetes mellitus[1][2][3][4][5][6][7][8].

Cat. No. 产品名称 纯度 描述 价格
HY-14806B Teneligliptin hydrobromide hydrate 99.00% Teneligliptin (MP-513) hydrobromide hydrate 是一种口服活性的和选择性的二肽基肽酶 4 (DPP-4) 抑制剂 (对人和大鼠酶的 IC50s 分别为 0.37 和 0.29 nM)。Teneligliptin hydrobromide hydrate 可改善血糖水平,可用于 2 型糖尿病相关的研究。

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规格 价格 是否有货 数量 操作
5 mg

¥343.00

In-stock
10 mg

¥500.00

In-stock
25 mg

¥860.00

In-stock
50 mg

¥1300.00

In-stock
100 mg

¥1950.00

In-stock
250 mg

¥3900.00

In-stock

References

[1]. Fukuda-Tsuru S, et al. A novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor, teneligliptin, improves postprandial hyperglycemia and dyslipidemia after single and repeated administrations. Eur J Pharmacol. 2012 Dec 5;696(1-3):194-202. [Content Brief]
[2]. Yoshida T, et al. Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorg Med Chem. 2012 Oct 1;20(19):5705-19. [Content Brief]
[3]. Guo D, et al. Beneficial effects of combination therapy of canagliflozin and teneligliptin on diabetic polyneuropathy and β-cell volume density in spontaneously type 2 diabetic Goto-Kakizaki rats. Metabolism. 2020 Jun;107:154232. [Content Brief]
[4]. Zhang GL, et al. Teneligliptin mitigates diabetic cardiomyopathy by inhibiting activation of the NLRP3 inflammasome. World J Diabetes. 2024 Apr 15;15(4):724-734. [Content Brief]
[5]. Fukuda-Tsuru S, et al. The novel dipeptidyl peptidase-4 inhibitor teneligliptin prevents high-fat diet-induced obesity accompanied with increased energy expenditure in mice. Eur J Pharmacol. 2014 Jan 15;723:207-15. [Content Brief]
[6]. Zhang Z, et al. Teneligliptin protects against hypoxia/reoxygenation-induced endothelial cell injury. Biomed Pharmacother. 2019 Jan;109:468-474. [Content Brief]
[7]. Peng W, et al. Teneligliptin prevents doxorubicin-induced inflammation and apoptosis in H9c2 cells. Arch Biochem Biophys. 2020 Apr 15;683:108238. [Content Brief]
[8]. Liu X, et al. Teneligliptin inhibits lipopolysaccharide-induced cytotoxicity and inflammation in dental pulp cells. Int Immunopharmacol. 2019 Aug;73:57-63. [Content Brief]

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