2567913-75-9

生物活性：MG-1102 是一流的单体 tau 和 pre-miRNA-146a 的双重结合剂。MG-1102 对 miRNA146a 具有特异性抑制作用，对双标记 pre-miRNA146a 和单标记 pre-miRNA146a 的 IC₅₀ 值分别为 0.21 μM 和 0.36 μM。MG-1102 与 tau 单体相互作用，通过表面等离子共振 (SPR) 测得 K_d 为 3.21 μM。MG-1102 是一种多靶标配体 (MTDL)，具有用于阿尔茨海默病 (AD) 的潜力。

MG-1102 is first-in-class dual binder of monomeric tau and pre-miRNA-146a. MG-1102 shows specific inhibition of miRNA146a with IC₅₀s of 0.21 mM and 0.36 mM specific inhibition of doublelabeled pre-miRNA146a and mono-labeled pre-miRNA146a, respectively. MG-1102 interacts with tau monomers with a K_d of 3.21 mM by surface plasmon resonance (SPR). MG-1102 is a potential multi-target-directed ligands (MTDLs) for Alzheimer’s disease (AD)^[1].