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生物活性：Phenamil methanesulfonate 是 Amiloride (HY-B0285) 的类似物，一种更有效且不可逆的上皮钠通道 (ENaC) 阻滞剂，IC₅₀ 为 400 nM。Phenamil methanesulfonate 也是 TRPP3 的竞争性抑制剂，在 Ca²⁺ 摄取实验中，抑制 TRPP3 介导的 Ca²⁺ 转运的 IC₅₀ 为 140 nM。Phenamil methanesulfonate 是一种通过强烈激活 BMP 信号通路来促进骨修复的小分子。Phenamil methanesulfonate 用于囊性纤维化肺疾病的相关研究。

Phenamil methanesulfonate, an analog of Amiloride (HY-B0285), is a more potent and less reversible epithelial sodium channel (ENaC) blocker with an IC₅₀ of 400 nM^[2]. Phenamil methanesulfonate is also a competive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca²⁺ transport with an IC₅₀ of 140 nM in a Ca²⁺ uptake assay^[1]. Phenamil methanesulfonate is an intriguing small molecule to promote bone repair by strongly activating BMP signaling pathway^[4]. Phenamil methanesulfonate is used for the research of cystic fibrosis lung disease^[5].