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生物活性：COX-2/5-LOX-IN-4 (Compound 1) 是一种双重抑制剂，通过同时作用于 COX-2 和 5-LOX，对 COX-2 的 IC₅₀ 为 0.05 μM，对 5-LOX 的 IC₅₀ 为 0.003 μM。COX-2/5-LOX-IN-4 通过抑制花生四烯酸代谢通路来降低前列腺素和白三烯的生成，从而缓解炎症反应。COX-2/5-LOX-IN-4 在大鼠耳水肿模型中通过静脉注射 (0.01 和 0.1 mg/kg) 分别降低 41% 和 44% 的水肿反应，展现出显著的抗炎效果。COX-2/5-LOX-IN-4 有望用于炎症性疾病机制的研究^[1]。

COX-2/5-LOX-IN-4 (Compound 1) is a dual inhibitor that acts on both COX-2 and 5-LOX, with IC₅₀ values of 0.05 μM for COX-2 and 0.003 μM for 5-LOX. By inhibiting the arachidonic acid metabolism pathway, COX-2/5-LOX-IN-4 reduces the production of prostaglandins and leukotrienes, alleviating inflammatory responses. In a rat ear edema model, intravenous administration (0.01 and 0.1 mg/kg) reduced edema by 41% and 44%, respectively, demonstrating significant anti-inflammatory effects. COX-2/5-LOX-IN-4 shows promise for studying the mechanisms of inflammatory diseases^[1].