2. GPCR/G Protein
  3. ICMT
  4. CAY10677

CAY10677 (compound 15) 是强效的 ICMT 抑制剂，可抑制癌细胞增殖。CAY10677 具有良好 PAMPA 渗透性。

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CAY10677 Chemical Structure

CAY10677 Chemical Structure

CAS No. : 1443253-20-0

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CAY10677 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAY10677 (compound 15) is a potent ICMT inhibitor that inhibits cancer cell proliferation. CAY10677 has good PAMPA penetration[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
1.65 μM
Compound: 15
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 23514631]
IMR-90 IC50
2.65 μM
Compound: 15
Antiproliferative activity against human IMR90 cells after 72 hrs by MTT assay
Antiproliferative activity against human IMR90 cells after 72 hrs by MTT assay
[PMID: 23514631]
MDA-MB-231 IC50
2.48 μM
Compound: 15
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 23514631]
MIA PaCa-2 IC50
1.6 μM
Compound: 15
Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay
Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay
[PMID: 23514631]
PC-3 IC50
2.55 μM
Compound: 15
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
[PMID: 23514631]
Sf9 IC50
0.86 μM
Compound: 15
Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-biotin-S-farnesyl-L-cysteine after 30 mins
Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-biotin-S-farnesyl-L-cysteine after 30 mins
[PMID: 23514631]
分子量

407.59

Formula

C25H37N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CAY10677 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAY106771443253-20-0CAY 10677CAY-10677ICMTIsoprenylcysteine carboxyl methyltransferasePAMPA permeabilityInhibitorinhibitorinhibit

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