CB1 inverse agonist 2 

CB1 inverse agonist 2 is an orally active inverse agonist of Cannabinoid Receptor CB1. CB1 inverse agonist 2 effectively inhibits CP55940-induced hypothermia and anorexia in mice model^[1].

CB1 inverse agonist 2 (compound 12 h) 对 CB1 具有选择性，对 CB1 和 CB2 的 pK_i 值分别为 9.7 和 6.0^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CB1 inverse agonist 2 (compound 12 h) (1 mg/kg; 腹腔注射; 单次剂量) 对体温降低的抑制程度达到 70%，(10mg /kg;口服; 单剂量) 对食物摄入的抑制率达到 59%^[1]。
CB1 inverse agonist 2 (10 mg/kg; 口服; 每天一次，持续 14 天) 导致小鼠体重与初始体重相比，出现 13% 的减轻^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

438.94

C₂₄H₂₀ClFN₂OS

1019839-52-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Synthesis and Evaluation of Dibenzothiazepines: A Novel Class of Selective Cannabinoid-1 Receptor Inverse Agonists J. Med. Chem., 2009, 52 (7), pp 1975-1982

  [2]. Pettersson H, et al. Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists. J Med Chem. 2009 Apr 9;52(7):1975-82.  [Content Brief]