2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. CCR1 antagonist 11 hydrochloride

CCR1 antagonist 11 hydrochloride 

目录号: HY-114097A
产品使用指南

摩尔计算器

CCR1 antagonist 11 hydrochloride (A1B1) 是一种具有口服活性的 CCR1 拮抗剂，作用于 hCCR1、 mCCR1、 rCCR1 的 IC50 值分别为 0.03 μM、0.58 μM、0.32 μM。CCR1 antagonist 11 hydrochloride 可用于类风湿性关节炎等相关炎症性疾病的研究。

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CCR1 antagonist 11 hydrochloride Chemical Structure

CCR1 antagonist 11 hydrochloride Chemical Structure

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CCR1 antagonist 11 hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 CCR 亚型特异性产品:

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist with the IC50 values of 0.03 μM, 0.58 μM and 0.32 μM for hCCR1, mCCR1 and rCCR1, respectively. CCR1 antagonist 11 hydrochloride can be used in the study of rheumatoid arthritis and other related inflammatory diseases[1].

IC50 & Target

IC50: 0.03 μM (hCCR1)，0.58 μM (mCCR1), 0.32 μM (rCCR1)[1].
体外研究
(In Vitro)

CCR1 antagonist 11 hydrochloride(A1B1) inhibits MIP-1α-induced Ca2+ mobilization in THP-1 cells with the IC50 value of 1 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CCR1 antagonist 11 hydrochloride 相关抗体:
体内研究
(In Vivo)

The pharmacokinetic parameters of CCR1 antagonist 11 hydrochloride(A1B1) in rat

Parameters PO (60 mg/kg)
t1/2 (h) 16.5
Cmax (μM/L) 0.85
AUC (h*ng/mL) 784
F (%) 95

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

466.38

Formula

C23H26Cl2FN3O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CCR1 antagonist 11 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCR1 antagonist 11CCRCC chemokine receptorCCR1hCCR1mCCR1rCCR1rheumatoid arthritisInhibitorinhibitorinhibit

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目录号：
HY-114097A
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