2. Apoptosis Anti-infection
  3. Apoptosis Bacterial Antibiotic
  4. Cefatrizine

Cefatrizine  (Synonyms: BL-S-640; SK&F 60771)

目录号: HY-123024
产品使用指南

摩尔计算器

Cefatrizine (BL-S-640) 是一种口服有效的广谱头孢菌素类抗生素。Cefatrizine 也是一种 eEF2K 抑制剂，在人乳腺癌细胞中具有抗增殖活性，可诱导 ER 应激，导致细胞死亡。Cefatrizine 可用于癌症和细菌感染的研究。

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Cefatrizine Chemical Structure

Cefatrizine Chemical Structure

CAS No. : 51627-14-6

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规格 是否有货
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Customer Review

Cefatrizine 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection[1][2].

IC50 & Target

β-lactam

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDA-MB-436 IC50
30 μM
Compound: 40
Anticancer activity against human MDA-MB-436 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
Anticancer activity against human MDA-MB-436 cells assessed as cell growth inhibition incubated for 24 hrs by MTT assay
[PMID: 33650861]
体外研究
(In Vitro)

Cefatrizine (0-100 µM; 24 h) causes a remarkable anti-proliferative effect on MCF-7 and MDA-MB-436 cell growth in a dose-dependent manner[1].
Cefatrizine (30 µM; 12 h) induces ER stress in breast cancer cells[1].
Cefatrizine (12, 24, 36 h) increases level of CHOP (marker of ER stress induced apoptosis) and promotes expressions of core proteins in eEF2K-modulated ER stress pathways (Bip, p-PERK, XBP-1S and p-JNK) in MCF-7 and MDA-MB-436 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cefatrizine 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7, MDA-MB-436 cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Led to a remarkable anti-proliferative effect on cells and resulted in almost 50% inhibition in the MCF-7 and MDA-MB-436 cells when at 33 µM and 29 µM.

Cell Viability Assay[1]

Cell Line: MCF-7, MDA-MB-436 cells
Concentration: 30 µM
Incubation Time: 12 h
Result: Led to massive cytoplasmic vacuolization.
体内研究
(In Vivo)

Cefatrizine (BL-S-640) (0.2, 1, 5, 25 mg/kg; p.o.; 4 times daily for 3 days) reduces the number of infecting organisms in the bladder and the kidneys in P. mirabilis intracystically infected model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MaleSwiss-Webster mice (19-21 g; P. mirabilis intracystically infected model)[2].
Dosage: 0.2, 1, 5, 25 mg/kg
Administration: Oral administration; 4 times daily for 3 days.
Result: Reduced the number of infecting organisms to less than 1,000 in the bladder when 1 mg/kg, and in the kidneys when 0.2 mg/kg.
分子量

462.50

Formula

C18H18N6O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
细胞实验： 

H2O 中的溶解度 : 250 mg/mL (540.54 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1622 mL 10.8108 mL 21.6216 mL
5 mM 0.4324 mL 2.1622 mL 4.3243 mL
查看完整储备液配制表

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Cefatrizine 相关分类

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1622 mL 10.8108 mL 21.6216 mL 54.0541 mL
5 mM 0.4324 mL 2.1622 mL 4.3243 mL 10.8108 mL
10 mM 0.2162 mL 1.0811 mL 2.1622 mL 5.4054 mL
15 mM 0.1441 mL 0.7207 mL 1.4414 mL 3.6036 mL
20 mM 0.1081 mL 0.5405 mL 1.0811 mL 2.7027 mL
25 mM 0.0865 mL 0.4324 mL 0.8649 mL 2.1622 mL
30 mM 0.0721 mL 0.3604 mL 0.7207 mL 1.8018 mL
40 mM 0.0541 mL 0.2703 mL 0.5405 mL 1.3514 mL
50 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0811 mL
60 mM 0.0360 mL 0.1802 mL 0.3604 mL 0.9009 mL
80 mM 0.0270 mL 0.1351 mL 0.2703 mL 0.6757 mL
100 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.5405 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefatrizine51627-14-6BL-S-640 SK&F 60771ApoptosisBacterialAntibioticP. mirabilisbacterialCHOPMCF-7MDA-MB-436breast cancerERInhibitorinhibitorinhibit

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