1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. Calcium Channel Chloride Channel
  3. Cerebrocrast

Cerebrocrast  (Synonyms: IOS-1.1212)

目录号: HY-106808
COA 产品使用指南

Cerebrocrast (IOS-1.1212) 是一种 1,4-二氢吡啶 (DHP) 衍生物。Cerebrocrast 对膜脂双层具有高亲和力,可轻松穿透血脑屏障并融入血浆和细胞器膜(包括线粒体的膜)。Cerebrocrast 促进大鼠肝线粒体中 H+ 和 Cl- 的共转运。Cerebrocrast 还具有神经保护和认知增强特性。

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Cerebrocrast Chemical Structure

Cerebrocrast Chemical Structure

CAS No. : 118790-71-9

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1 mg ¥2600
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5 mg ¥5900
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cerebrocrast (IOS-1.1212) is a 1,4-dihydropyridine (DHP) derivative. Cerebrocrast has a high affinity for the membrane lipid bilayer and it can easily penetrate the blood-brain barrier and incorporate into the plasma and organelle membranes, including those of mitochondria. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Cerebrocrast also exhibits neuroprotective and cognition enhancer properties[1][2].

体外研究
(In Vitro)

Cerebrocrast (25 μM) 抑制大鼠肝线粒体内线粒体阴离子通道,其 IC50 值为 10.5 ± 2.0 μM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

511.56

Formula

C26H35F2NO7

CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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