2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. Ceronapril

Ceronapril  (Synonyms: Ceranapril; SQ 29852)

目录号: HY-106816
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摩尔计算器

Ceronapril (SQ 29852) 是一种有效的和具有口服活性的血管紧张素转换酶 (ACE) 抑制剂， IC50 为 36 nM。

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Ceronapril Chemical Structure

Ceronapril Chemical Structure

CAS No. : 111223-26-8

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Ceronapril 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ceronapril (SQ 29852) is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with an IC50 of 36 nM[1].

IC50 & Target

IC50: 36 nM (ACE)[1]
体内研究
(In Vivo)

Ceronapril (SQ 29852) 在雄性 SD 大鼠中抑制 ACE，静脉注射和口服的 ED50 分别为 0.063 μM/kg 和 0.53 μM/kg[1]。
Ceronapril (100 mg/kg; p.o.; single dose or twice daily for 3 days) 阻断大鼠外周部位的 ACE [2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[2]
Dosage: 100 mg/kg
Administration: PO, twice daily for 3 days or single daily dose
Result: Showed clear inhibition of ACE in the 2 circumventricular organs-the subfornical organ and the lamina terminals-but no change in other regions of the brain after chronic treatment. Inhibited ACE in plasma, kidney and lung rapidly (3 hr) after a single administration. Did not inhibit ACE in structures of the brain within the blood-brain barrier, such as the caudate-putamen, choroid plexus, globus pallidus, supraoptic nucleus and paraventricular nucleus of the hypothalamus.
分子量

440.47

Formula

C21H33N2O6P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ceronapril 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

Ceronapril111223-26-8Ceranapril SQ 29852SQ29852SQ 29852SQ-29852Angiotensin-converting Enzyme (ACE)SD ratskidneylungorally activeInhibitorinhibitorinhibit

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