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CFM-1 是 CARP-1/APC-2 结合的小分子拮抗剂，EC50 值为 4.1 μM。CFM-1 可以诱导 G2M 期细胞周期停滞，并抑制人乳腺癌细胞的活性。

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CFM-1 Chemical Structure

CFM-1 Chemical Structure

CAS No. : 1380448-60-1

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CFM-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC50 value of 4.1 μM. CFM-1 induces G2M cell cycle arrest and suppresses viabilities of human breast cancer cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Daoy IC50
8.12 μg/mL
Compound: CFM-1
Cytotoxicity against human DaOY cells assessed as inhibition of cell survival after 24 hrs by MTT assay
Cytotoxicity against human DaOY cells assessed as inhibition of cell survival after 24 hrs by MTT assay
[PMID: 25555142]
HeLa IC50
13.5 μg/mL
Compound: CFM-1
Cytotoxicity against human HeLa cells assessed as inhibition of cell survival after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell survival after 24 hrs by MTT assay
[PMID: 25555142]
Huh-7 IC50
8.18 μg/mL
Compound: CFM-1
Cytotoxicity against human HuH7 cells assessed as inhibition of cell survival after 24 hrs by MTT assay
Cytotoxicity against human HuH7 cells assessed as inhibition of cell survival after 24 hrs by MTT assay
[PMID: 25555142]
MDA-MB-231 IC50
19.7 μg/mL
Compound: CFM-1
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell survival after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell survival after 24 hrs by MTT assay
[PMID: 25555142]
分子量

355.23

Formula

C12H7BrN2O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CFM-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFM-11380448-60-1CFM1CFM 1OthersCARP-1/APC-2 bindingcell cycle arresthuman breast cancer cellsInhibitorinhibitorinhibit

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目录号：
HY-116473
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