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  3. Chiglitazar sodium

Chiglitazar sodium  (Synonyms: Carfloglitazar sodium)

目录号: HY-106266B
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Chiglitazar (Carfloglitazar) 是泛过氧化物酶体增殖物激活受体 (PPARα/γ) 的双激动剂,其对 PPARα,PPARγPPARδEC50 值分别为 1.2,0.08 和 1.7 μM。

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Chiglitazar sodium Chemical Structure

Chiglitazar sodium Chemical Structure

CAS No. : 2390374-10-2

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Chiglitazar sodium 的其他形式现货产品:

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查看 PPAR 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chiglitazar (Carfloglitazar) is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively.

IC50 & Target

PPARα

1.8 μM (EC50)

PPAR-γ

0.08 μM (EC50)

PPAR-δ

1.7 μM (EC50)

体外研究
(In Vitro)

Chiglitazar 与 Rosiglitazone 和 Pioglitazone 对 PPARγ 以及 WY14643 对 PPARα 进行了比较剂量反应研究。Chiglitazar 显示两种亚型的显著激活。Chiglitazar 的 PPARγ 激活活性弱于 Rosiglitazone,但强于 Pioglitazone。在 PPARα 激活方面,Chiglitazar 显示出比 Rosiglitazone、Pioglitazone 或选择性 PPARα 激动剂 WY14643 更有效的活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

注射胰岛素后,与用载体处理的对照组相比,用 Chiglitazar 或 Rosiglitazone 处理的 MSG 大鼠的血浆葡萄糖水平在所有时间点均显著降低。用 Chiglitazar 和 Rosiglitazone 处理的动物的空腹 PI 水平低于对照。用 Chiglitazar 和 Rosiglitazone 处理的 MSG 肥胖大鼠的 ISI 显著高于对照组。此外,Chiglitazar 改善了 HOMA 指数。对于 IPGTT,在葡萄糖负荷后 30 分钟,5 和 10 mg / kg Chiglitazar 和 Rosiglitazone 处理组的葡萄糖值显著低于载体处理组。处理组 IPGTT 期间葡萄糖反应积分显著低于对照组[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

594.61

Formula

C36H28FN2NaO4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Chiglitazar sodium
目录号:
HY-106266B
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