2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. CHK1-IN-3

CHK1-IN-3 是一种检测点激酶 (CHK1) 抑制剂，IC50 值为 0.4 nM。

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CHK1-IN-3 Chemical Structure

CHK1-IN-3 Chemical Structure

CAS No. : 2097252-39-4

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规格 价格 是否有货 数量
1 mg ￥1613
In-stock
5 mg ￥3738
In-stock
10 mg ￥5488
In-stock
25 mg 现货 询价
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

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Customer Review

CHK1-IN-3 相关抗体

Top Publications Citing Use of Products

查看 Checkpoint Kinase (Chk) 亚型特异性产品:

查看所有亚型
Chk1 Chk2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHK1-IN-3 is a Checkpoint Kinase 1 (CHK1) inhibitor with an IC50 of 0.4 nM[1].

IC50 & Target[1]

Chk1

0.4 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
> 40 μM
Compound: (R)-17
Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated patch clamp assay
Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated patch clamp assay
[PMID: 30986571]
JeKo-1 IC50
0.036 μM
Compound: (R)-17
Inhibition of human JeKo1 cells incubated for 72 hrs by cellTiter 96 aqueous one solution reagent based assay
Inhibition of human JeKo1 cells incubated for 72 hrs by cellTiter 96 aqueous one solution reagent based assay
[PMID: 30986571]
MV4-11 IC50
0.039 μM
Compound: (R)-17
Inhibition of human MV411 cells incubated for 72 hrs by cellTiter 96 aqueous one solution reagent based assay
Inhibition of human MV411 cells incubated for 72 hrs by cellTiter 96 aqueous one solution reagent based assay
[PMID: 30986571]
Ramos IC50
0.095 μM
Compound: (R)-17
Inhibition of human Ramos cells incubated for 72 hrs by cellTiter 96 aqueous one solution reagent based assay
Inhibition of human Ramos cells incubated for 72 hrs by cellTiter 96 aqueous one solution reagent based assay
[PMID: 30986571]
RPMI-8226 IC50
1.991 μM
Compound: (R)-17
Inhibition of human RPMI8226 cells incubated for 72 hrs by cellTiter 96 aqueous one solution reagent based assay
Inhibition of human RPMI8226 cells incubated for 72 hrs by cellTiter 96 aqueous one solution reagent based assay
[PMID: 30986571]
Z-138 IC50
0.012 μM
Compound: (R)-17
Inhibition of human Z138 cells incubated for 72 hrs by cellTiter 96 aqueous one solution reagent based assay
Inhibition of human Z138 cells incubated for 72 hrs by cellTiter 96 aqueous one solution reagent based assay
[PMID: 30986571]
体外研究
(In Vitro)

CHK1-IN-3 effectively inhibites the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 µM) and displays low affinity for hERG (IC50 > 40 µM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CHK1-IN-3 相关抗体:
体内研究
(In Vivo)

CHK1-IN-3 significantly suppresses the tumor growth in Z-138 cell inoculated xenograft model as a single agent with body weight unaffected[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

405.46

Formula

C20H23N9O
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 125 mg/mL (308.29 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4663 mL 12.3317 mL 24.6633 mL
5 mM 0.4933 mL 2.4663 mL 4.9327 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

CHK1-IN-3 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4663 mL 12.3317 mL 24.6633 mL 61.6584 mL
5 mM 0.4933 mL 2.4663 mL 4.9327 mL 12.3317 mL
10 mM 0.2466 mL 1.2332 mL 2.4663 mL 6.1658 mL
15 mM 0.1644 mL 0.8221 mL 1.6442 mL 4.1106 mL
20 mM 0.1233 mL 0.6166 mL 1.2332 mL 3.0829 mL
25 mM 0.0987 mL 0.4933 mL 0.9865 mL 2.4663 mL
30 mM 0.0822 mL 0.4111 mL 0.8221 mL 2.0553 mL
40 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5415 mL
50 mM 0.0493 mL 0.2466 mL 0.4933 mL 1.2332 mL
60 mM 0.0411 mL 0.2055 mL 0.4111 mL 1.0276 mL
80 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.7707 mL
100 mM 0.0247 mL 0.1233 mL 0.2466 mL 0.6166 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHK1-IN-32097252-39-4Checkpoint Kinase (Chk)Inhibitorinhibitorinhibit

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产品名称：
CHK1-IN-3
目录号：
HY-128601
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