2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. Chk2-IN-1

Chk2-IN-1 (compound 1) 是一种有效和选择性的 checkpoint kinase 2 (Chk2) 抑制剂，抑制 Chk2 和 Chk1 的 IC50 值分别为 13.5 nM 和 220.4 nM。Chk2-IN-1 可引发强烈的共济失调毛细血管扩张突变 (ATM) 依赖性 Chk2 介导的辐射防护作用。

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Chk2-IN-1 Chemical Structure

Chk2-IN-1 Chemical Structure

CAS No. : 724708-21-8

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Chk2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Checkpoint Kinase (Chk) 亚型特异性产品:

查看所有亚型
Chk1 Chk2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect[1].

IC50 & Target[1]

Chk2

13.5 nM (IC50)

Chk1

220.4 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM GI50
1.7 μM
Compound: 4
Growth inhibition of human CCRF-CEM cells up to 48 hrs by trypan blue exclusion assay
Growth inhibition of human CCRF-CEM cells up to 48 hrs by trypan blue exclusion assay
[PMID: 22995819]
Jurkat IC50
3.5 μM
Compound: 4
Inhibition of PMA- and PHA-stimulated IL2 production in human Jurkat T cells incubated for 30 mins prior to PMA- and PHA-stimulation by competitive enzyme immunoassay
Inhibition of PMA- and PHA-stimulated IL2 production in human Jurkat T cells incubated for 30 mins prior to PMA- and PHA-stimulation by competitive enzyme immunoassay
[PMID: 22995819]
Jurkat IC50
3.55 μM
Compound: 2
Inhibition of IL-2 production was determined in Jurkat cells after PMA/PHA activation by Enzyme immunoassay
Inhibition of IL-2 production was determined in Jurkat cells after PMA/PHA activation by Enzyme immunoassay
[PMID: 15214798]
THP-1 IC50
8.16 μM
Compound: 2
Inhibition of TNF-alpha production was determined in THP-1cells after LPS activation by Enzyme immunoassay
Inhibition of TNF-alpha production was determined in THP-1cells after LPS activation by Enzyme immunoassay
[PMID: 15214798]
THP-1 IC50
8.2 μM
Compound: 4
Inhibition of LPS-induced TNFalpha production in human THP1 cells incubated for 30 mins prior to LPS-challenge by competitive enzyme immunoassay
Inhibition of LPS-induced TNFalpha production in human THP1 cells incubated for 30 mins prior to LPS-challenge by competitive enzyme immunoassay
[PMID: 22995819]
分子量

295.30

Formula

C15H13N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chk2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chk2-IN-1724708-21-8Checkpoint Kinase (Chk)ATMradioprotectionataxia telangiectasia mutatedInhibitorinhibitorinhibit

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目录号：
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