2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Toll-like Receptor (TLR) Reactive Oxygen Species NF-κB
  4. Chlojaponilactone B

Chlojaponilactone B 是一种具有抗炎特性的茚烷型倍半萜类化合物。Chlojaponilactone B 通过抑制 TLR4 并随后减少活性氧 (ROS) 的产生、下调 NF-κB 来抑制炎症反应，从而减少促炎细胞因子 iNOS、NO、COX-2、IL-6 和 TNF-α 的表达。

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Chlojaponilactone B Chemical Structure

Chlojaponilactone B Chemical Structure

CAS No. : 1449382-91-5

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规格 价格 是否有货 数量
1 mg ￥3430
1 - 2 周
5 mg 现货 1 - 2 周
10 mg   询价  
50 mg   询价  

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Chlojaponilactone B 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α[1].

分子量

286.32

Formula

C17H18O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chlojaponilactone B 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlojaponilactone B1449382-91-5Toll-like Receptor (TLR)Reactive Oxygen SpeciesNF-κBNuclear factor-κBNuclear factor-kappaBTLR4ROSiNOSNOCOX-2IL-6TNF-α anti-inflammatory propertiesInhibitorinhibitorinhibit

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