2. Anti-infection Others
  3. Antibiotic Bacterial Isotope-Labeled Compounds
  4. Chlorhexidine-d8

Chlorhexidine-d8 是氘代标记的 Chlorhexidine (HY-B1248)。

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Chlorhexidine-d<sub>8</sub> Chemical Structure

Chlorhexidine-d8 Chemical Structure

CAS No. : 1246816-96-5

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Other Forms of Chlorhexidine-d8:

Chlorhexidine-d8 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chlorhexidine-d8 is deuterium-labeled Chlorhexidine (HY-B1248)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Fibroblast CC50
6.32 μg/mL
Compound: Chlorohexidine
Cytotoxicity against human skin fibroblasts assessed as cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human skin fibroblasts assessed as cell viability measured after 72 hrs by MTT assay
[PMID: 33385851]
HEK293 IC50
0.21 μM
Compound: chlorhexidine
Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
[PMID: 23241029]
HEK293 IC50
0.4 μM
Compound: chlorhexidine
Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
[PMID: 23241029]
HEK293 IC50
0.41 μM
Compound: chlorhexidine
Inhibition of human OCT3-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
Inhibition of human OCT3-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
[PMID: 23241029]
HEK293 IC50
0.5 μM
Compound: chlorhexidine
Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
[PMID: 23241029]
HEK293 IC50
0.7 μM
Compound: chlorhexidine
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
[PMID: 23241029]
HEK293 CC50
7.28 μg/mL
Compound: Chlorohexidine
Cytotoxicity against human HEK293 cells assessed as cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HEK293 cells assessed as cell viability measured after 72 hrs by MTT assay
[PMID: 33385851]
HSF (VGS) CC50
5.48 μg/mL
Compound: Chlorhexidine
Cytotoxicity against human HSF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HSF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33310546]
HT-22 IC50
5.6 μM
Compound: 34
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 36876904]
体外研究
(In Vitro)

稳定或放射性同位素标记的化合物可以精确追踪和量化代谢途径中的单个原子。稳定同位素一般不改变分子性质，但可能轻微影响代谢动力学；放射性同位素可能干扰细胞。标记可以区分内源性和外源性代谢物，减少假阳性，对定量和重建代谢通路有利[2]。
在细胞培养或酶反应中，利用同位素标记物可精确控制浓度和暴露时间，便于研究代谢反应和酶活性。通过稳定同位素解析代谢组学 (SIRM)，可以研究细胞代谢网络，鉴定关键代谢节点和调控机制，为化合物开发提供靶标。
同位素标记化合物可用于竞争结合实验，评估化合物与受体的亲和力和结合动力学，助于优化设计。稳定同位素标记物在质谱分析中作为内标，提高分析准确性和重现性，减少基质效应干扰[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chlorhexidine-d8 相关抗体:
体内研究
(In Vivo)

同位素标记物通过质谱 (MS) 和核磁共振 (NMR) 等技术，能够无创地跟踪化合物及其代谢产物在体内的分布、转化和清除，有利于药物代谢动力学 (ADME) 的研究。
同位素标记可以揭示代谢途径中的具体步骤。直接在人体或动物模型中使用在特定位置具有稳定同位素标记的化合物，还有助于验证药物机制和评估意外副作用，提高临床研究的准确性和效率[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

513.50

Formula

C22H22D8Cl2N10
CAS 号
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chlorhexidine-d8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlorhexidine-d81246816-96-5AntibioticBacterialIsotope-Labeled CompoundsInhibitorinhibitorinhibit

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