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  4. Cholest-5-ene-3ß,22(S)-diol

Cholest-5-ene-3ß,22(S)-diol  (Synonyms: (22S)-Hydroxycholesterol)

目录号: HY-137307
产品使用指南

摩尔计算器

Cholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) 是一种口服有效的兹醇，对人前核细胞白血病细胞无明显细胞毒性，氧化和/或炎症作用。Cholest-5-ene-3ß,22(S)-diol 在大鼠模型中会抑制体重增加，增加血清中三酰甘油 (TAG) 水平。

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Cholest-5-ene-3ß,22(S)-diol Chemical Structure

Cholest-5-ene-3ß,22(S)-diol Chemical Structure

CAS No. : 22348-64-7

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规格 价格 是否有货
5 mg ￥4250
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Other Forms of Cholest-5-ene-3ß,22(S)-diol:

Cholest-5-ene-3ß,22(S)-diol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models[1][2].

体外研究
(In Vitro)

Cholest-5-ene-3ß,22(S)-diol (10 μg/mL, 20 μg/mL; 24 h) 对 U937 细胞磷脂酰丝氨酸外化、线粒体跨膜电位、细胞对碘化丙啶的通透性和细胞核形态变化无影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cholest-5-ene-3ß,22(S)-diol 相关抗体:
体内研究
(In Vivo)

Cholest-5-ene-3ß,22(S)-diol (30 mg/kg; 口服; 在加饮食中，共处理 3 周) 减少体重增加，消除高脂饮食引起的血清中三酰甘油 (TAG) 水平的增加[2]。

在大鼠中的药代动力学分析[2]

Route Dose (mg/kg) Cmax (ng/mL) Tmax (h) AUCt (ng·h/mL) AUC (ng·h/mL) T1/2 (h) Extent of tritium exchange (%)
i.v. 50 22.4 0.08 174 195 8.1 2.8
p.o. 50 7.5 4 95.2 104 6.4 1.2

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats injected with Pentobarbital (20 mg, 50 mg/mL; i.p.)[2]
Dosage: 30 mg/kg/day
Administration: Oral gavage; 3 weeks consecutively
Result: Decreased body weight gain significantly after 1 week treatment.
Increased gene expression of Ucp3 and Cpt2 in liver and skeletal muscle, and increased protein level of Ucp3 in skeletal muscle after 3 weeks treatment.
分子量

402.65

Formula

C27H46O2
CAS 号
中文名称

22(S)-羟基胆固醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cholest-5-ene-3ß,22(S)-diol 相关分类

  • 摩尔计算器

  • 稀释计算器

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质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cholest-5-ene-3ß,22(S)-diol22348-64-7(22S)-Hydroxycholesterol22(S)-羟基胆固醇OthersInhibitorinhibitorinhibit

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