2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Chrodrimanin B

Chrodrimanin B 是一种真菌的代谢产物，一种有效的，非开放 B.?mori GABAR RDL 通道阻断剂，IC50 为1.13 nM。Chrodrimanin B 衰减RDL GABA反应的峰值电流振幅，IC50 为 1.66 nM。Chrodrimanin B 是一种半萜类化合物，具有杀虫活性。

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Chrodrimanin B Chemical Structure

Chrodrimanin B Chemical Structure

CAS No. : 132196-54-4

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Chrodrimanin B 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chrodrimanin B, a metabolite of a fungal, is a potent, non-open-channel-blocking antagonist on?B.?mori GABAR RDL with an IC50?of 1.13 nM. Chrodrimanin B attenuates the peak current amplitude of the GABA response of RDL with an IC50?of 1.66 nM.?Chrodrimanin B, a meroterpenoid, shows insecticidal activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 50 μM
Compound: 5
Cytotoxicity against human A549 cells by sulforhodamine B assay
Cytotoxicity against human A549 cells by sulforhodamine B assay
[PMID: 26046820]
HeLa IC50
> 50 μM
Compound: 5
Cytotoxicity against human HeLa cells by sulforhodamine B assay
Cytotoxicity against human HeLa cells by sulforhodamine B assay
[PMID: 26046820]
HL-60 IC50
> 50 μM
Compound: 5
Cytotoxicity against human HL60 cells by sulforhodamine B assay
Cytotoxicity against human HL60 cells by sulforhodamine B assay
[PMID: 26046820]
K562 IC50
> 50 μM
Compound: 5
Cytotoxicity against human K562 cells by sulforhodamine B assay
Cytotoxicity against human K562 cells by sulforhodamine B assay
[PMID: 26046820]
MDCK IC50
55 μM
Compound: 5
Antiviral activity against influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells incubated for 48 hrs assessed as inhibition of virus-induced cytopathic effect by crystal violet staining assay
Antiviral activity against influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells incubated for 48 hrs assessed as inhibition of virus-induced cytopathic effect by crystal violet staining assay
[PMID: 26046820]
体外研究
(In Vitro)

Chrodrimanin B exhibits much weaker blocking action on human α1β2γ2 GABAR compared to RDL (IC50=1.48 μM)[1].
Chrodrimanin B shows competitive actions at low concentrations and non-competitive actions at higher concentrations on?B.?mori GABAR RDL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Chrodrimanin B 相关抗体:
分子量

484.54

Formula

C27H32O8
CAS 号
结构分类
初始来源

Aspergillus sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chrodrimanin B 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chrodrimanin B132196-54-4GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorFungal metaboliteGABAR RDLinsecticidal activityα1β2γ2 GABARInhibitorinhibitorinhibit

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目录号：
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