CKS-17 

CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions^[1][2][3].

CKS-17 (THP-1 cells) induces increased intracellular cAMP via activation of adenylate cyclase^[1].
CKS-17 (15 μM; EL4 cells) inhibits interleukin-2 production by tumor cell products^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CKS-17 (10 μM; i.d.; B6AF1 mice and C57BL/6J mice) inhibits delayed-type hypersensitivity (DTH) reactions to sheep erythrocytes in the feet of mice^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1942.27

C₈₇H₁₄₈N₂₆O₂₄

99273-04-8

LQNRRGLDLLFLKEGGL

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Haraguchi S, et, al. Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections. Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5568-71.  [Content Brief]

  [2]. Nelson M, et, al. Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products. Cancer Immunol Immunother. 1989;30(2):113-8.  [Content Brief]

  [3]. Nelson M, et, al. Inhibition of interleukin-2 production by tumor cell products and by CKS-17, a synthetic retroviral envelope peptide. Cancer Immunol Immunother. 1990;30(6):331-41.  [Content Brief]