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  4. CL-385319

CL-385319是一种N-替代哌啶化合物，具有抑制H5N1禽流感A病毒感染的活性。CL-385319在Madin-Darby犬肾细胞(MDCK)中对高度致病性的H5N1病毒的感染表现出IC50为27.03±2.54 μM的效果。CL-385319具有低细胞毒性，CC50为1.48 mM，能够抑制携带不同来源H5N1毒株的假病毒入侵，但对VSV-G假型粒子的进入没有抑制作用。CL-385319具有HA1中的M24A突变或HA2中的F110S突变的假病毒对CL-385319具有抗性，表明这两个残基在腔体区域可能对CL-385319的结合至关重要。

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CL-385319 Chemical Structure

CL-385319 Chemical Structure

CAS No. : 1210501-46-4

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CL-385319 相关抗体

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生物活性

CL-385319 is an N-substituted piperidine compound with inhibitory activity against H5N1 avian influenza A virus infection. CL-385319 exhibited an IC50 of 27.03±2.54 μM against infection of highly pathogenic H5N1 virus in Madin-Darby canine kidney cells (MDCK). CL-385319 had low cytotoxicity with a CC50 of 1.48 mM and was able to inhibit the entry of pseudoviruses carrying H5N1 strains from different sources, but had no inhibitory effect on the entry of VSV-G pseudotyped particles. Pseudoviruses with the M24A mutation in HA1 or the F110S mutation in HA2 were resistant to CL-385319, indicating that these two residues in the cavity region may be critical for the binding of CL-385319[1].

分子量

354.77

Formula

C15H19ClF4N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CL-385319 相关分类

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Keywords:

CL-3853191210501-46-4CL385319CL 385319OthersInhibitorinhibitorinhibit

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