2. GPCR/G Protein Neuronal Signaling
  3. Neurotensin Receptor
  4. Contulakin G

Contulakin G 是一种 O-糖基化无脊椎动物神经紧张素。Contulakin-G 是一种较弱的神经紧张素受体 (neurotensin receptor) 激动剂。Contulakin G 还是一种有效的镇痛剂。

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Custom Peptide Synthesis

Contulakin G Chemical Structure

Contulakin G Chemical Structure

CAS No. : 229180-41-0

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Contulakin G 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Contulakin G is an O-glycosylated invertebrate neurotensin. Contulakin-G is a weaker agonist for the neurotensin receptor. Contulakin G is also a potent antinociceptive agent[1][2].

体内研究
(In Vivo)

Contulakin G exhibits potent analgesic activity in three pain models in rats following intrathecal delivery, namely in tail-flick (acute pain), formalin test, and CFA-induced allodynia inflammatory pain[1].
Contulakin G (0-3 nmoL, Intrathecally) significantly decreases flinching behavior in rats[2].
Contulakin G (50-500 nmoL, Intrathecally) produces a dose-dependent increase in the thermally evoked skin twitch latency by 30 min after administration in dogs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Holtzman rats (300-375 g)[2]
Dosage: 0.03, 0.1, 0.3, and 3 nmol
Administration: Intrathecally, administered as a 10-μL bolus followed by a 10-μL saline flush
Result: Produced a significant decrease in flinching in all phases of the formalin test in rats.
Animal Model: Purpose-bred beagle dogs (9-12 kg)[2]
Dosage: 50, 150, or 500 nmol
Administration: Intrathecally
Result: Produced a dose-dependent increase in the thermally evoked skin twitch latency at 30 min after dosing in dogs, which reached statistical difference as compared to vehicle at 500 nmol.
分子量

2070.17

Formula

C88H140N20O37
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

Contulakin G 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Contulakin G229180-41-0Neurotensin Receptoranalgesic activityglycopeptideConus geographusInhibitorinhibitorinhibit

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目录号：
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