2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. Cortistatin-29

Cortistatin-29 是一种神经肽，可减轻神经性疼痛。Cortistatin-29 以高亲和力结合所有生长抑素 (SS) 受体亚型，对 SSTR1、SSTR2、SSTR3、 SSTR4、SSTR5 的 < b>IC50 值分别为 2.8 nM、7.1 nM、0.2 nM、3.0 nM、13.7 nM。Cortistatin-29 显示出抗纤维化作用。

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Custom Peptide Synthesis

Cortistatin-29 Chemical Structure

Cortistatin-29 Chemical Structure

CAS No. : 1815618-17-7

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Cortistatin-29 相关抗体

Top Publications Citing Use of Products

查看 Somatostatin Receptor 亚型特异性产品:

查看所有亚型
SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects[1][2][3][4].

IC50 & Target[3]

SSTR1

2.8 nM (IC50)

SSTR2

7.1 nM (IC50)

SSTR3

0.2 nM (IC50)

SSTR4

3.0 nM (IC50)

SSTR5

13.7 nM (IC50)

体内研究
(In Vivo)

Cortistatin 29 (1-2 µg) 可缓解小鼠慢性神经性疼痛[1]。
Cortistatin 29 (1 nmol/小鼠；腹腔注射；每周三次) 在小鼠中表现出抗纤维化作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20-24 g body weight, 8-12 weeks-old mice[1]
Dosage: 1 µg in 20 µL for s.c.; 2 µg in 200 µL for i.p.; 20 ng in 10 µL for i.t.
Administration: Every other day for 12 days
Result: Ameliorated hyperalgesia and allodynia, regulated the nerve damageinduced hypersensitization of primary nociceptors, inhibited neuroinflammatory responses, and enhanced the production of neurotrophic factors both at the peripheral and central levels.
分子量

3540.04

Formula

C161H240N46O41S2
CAS 号
Sequence

{Glp}-Glu-Arg-Pro-Pro-Leu-Gln-Gln-Pro-Pro-His-Arg-Asp-Lys-Lys-Pro-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys (disulfide bridge: Cys17-Cys28)
Sequence Shortening

{Glp}-ERPPLQQPPHRDKKPCKNFFWKTFSSCK (disulfide bridge: Cys17-Cys28)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cortistatin-29 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cortistatin-291815618-17-7Cortistatin29Cortistatin 29Somatostatin ReceptorSSTRsSSTRanti-fibroticneuropathic painneuropeptidecontractile fibersInhibitorinhibitorinhibit

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