Somatostatin Receptor Inhibitors

SSTR2

SSTR3

SSTR5

SSTR1

SSTR2

SSTR3

SSTR5

SSTR4

SSTR1, IC₅₀: 2.8 nM

SSTR2, IC₅₀: 7.1 nM

SSTR3, IC₅₀: 0.2 nM

SSTR5, IC₅₀: 13.7 nM

SSTR4, IC₅₀: 3.0 nM

SSTR2

SSTR3

SSTR5

SSTR2

SSTR5

SSTR1

SSTR4

hsst₁, Ki: >1000 nM

hsst₂, Ki: 12 nM
hsst₂, IC₅₀: 1.8 nM (rat antagonist bioassay versus somatostatin)

hsst₃, Ki: 100 nM

hsst₅, Ki: 520 nM

hsst₄, Ki: 895 nM

SSTR5

SSTR1

SSTR1, IC₅₀: 2.8 nM

SSTR2, IC₅₀: 7.1 nM

SSTR3, IC₅₀: 0.2 nM

SSTR5, IC₅₀: 13.7 nM

SSTR4, IC₅₀: 3.0 nM

SSTR2, EC₅₀: 37.6 nM

SSTR3, EC₅₀: 31.3 nM

SSTR4, EC₅₀: 10.5 nM

SSTR2, EC₅₀: 37.6 nM

SSTR3, EC₅₀: 31.3 nM

SSTR4, EC₅₀: 10.5 nM

SSTR2

hsst₁, Ki: 1000 nM

hsst₂, Ki: 17 nM

hsst₃, Ki: 66 nM

hsst₅, Ki: 6 nM

hsst₄, Ki: 1000 nM

SSTR2

SSTR2

SSTR2, IC₅₀: 0.63 nM

SSTR5, IC₅₀: 0.65 nM

SSTR2

SSTR2

SSTR2

SSTR3

SSTR5

SSTR2

SSTR3

SSTR5

SSTR3

SSTR2, Ki: 0.025 nM
SSTR2, IC₅₀: 4.8 nM

SSTR2

SSTR5