2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor Urotensin Receptor
  4. PRL 3195

PRL 3195 是一种 somatostatin receptor 拮抗剂，对人生长抑素受体 sst5、sst2、sst3、sst1 和 sst4 的 Ki 分别为 6、17、66、1000 和 1000 nM。

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Custom Peptide Synthesis

PRL 3195 Chemical Structure

PRL 3195 Chemical Structure

CAS No. : 341519-04-8

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规格 是否有货
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100 mg   询价  
250 mg   询价  

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Customer Review

PRL 3195 相关抗体

Top Publications Citing Use of Products

查看 Somatostatin Receptor 亚型特异性产品:

查看所有亚型
SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PRL 3195 is a somatostatin receptor antagonist with Kis of 6, 17, 66, 1000 and 1000 nM for human somatostatin receptors (sst5, sst2, sst3, sst1 and sst4, respectively)[1].

IC50 & Target[1]

hsst5

6 nM (Ki)

hsst2

17 nM (Ki)

hsst3

66 nM (Ki)

hsst1

1000 nM (Ki)

hsst4

1000 nM (Ki)

rat urotensin II receptor

429 nM (Ki)

human urotensin II receptor

1846 nM (Ki)

体外研究
(In Vitro)

PRL 3195 抑制人尿紧素 II (human urotensin II) 诱导的大鼠主动脉相位振荡，ED50 为 24 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PRL 3195 相关抗体:
分子量

1177.83

Formula

C58H69ClN12O9S2
CAS 号
Sequence

{Phe<4Cl>}-{d-Cys}-{β-Ala<3-Py>}-{d-Trp}-{Lys<N2-Me>}-Thr-Cys-{2-Nal}-NH2 (Disulfide bridge:Cys2-Cys7)
Sequence Shortening

{F<4Cl>}-{d-C}-{β-A<3-Py>}-{d-W}-{K<N2-Me>}-TC-{2-Nal}-NH2 (Disulfide bridge:Cys2-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

PRL 3195 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRL 3195341519-04-8PRL3195PRL-3195Somatostatin ReceptorUrotensin ReceptorSSTRsSSTRUT receptorInhibitorinhibitorinhibit

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产品名称：
PRL 3195
目录号：
HY-P4469
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