2. GPCR/G Protein
  3. GCGR
  4. Cotadutide

Cotadutide  (Synonyms: MEDI0382)

目录号: HY-P2231 纯度: 98.88%
COA 产品使用指南

摩尔计算器

Cotadutide (MEDI0382) 是一种有效的胰高血糖素样肽-1 (GLP-1) 和胰高血糖素受体 (GCGR) 双重激动剂，EC50 值分别为 6.9 pM 和 10.2 pM。Cotadutide 可促进减肥，控制血糖，以及减轻纤维化。Cotadutide 可用于肥胖和 2 型糖尿病 (T2D) 的研究。

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Cotadutide Chemical Structure

Cotadutide Chemical Structure

CAS No. : 1686108-82-6

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规格 价格 是否有货 数量
1 mg ￥1850
In-stock
5 mg ￥5600
In-stock
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Cotadutide:

Cotadutide 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D)[1][2][3].

IC50 & Target

EC50: 6.9 pM (GLP-1); 10.2 pM (GCGR)[1]
体外研究
(In Vitro)

Cotadutide stimulates a concentration-dependent increase in cAMP accumulation in rat (INS-1 832/3) and human (EndoC-βH1) β-cell lines (EC50: 226 pM and 1051 pM, respectively?), as well as rat, mouse and human hepatocytes (EC50: 462 pM, 840 pM, 1447 pM, respectively)[1].
Cotadutide (100 pM-1 μM) potentiates glucose-stimulated insulin secretion in the rat (INS-1 832/3) pancreatic β‐cell line and increases glucose output in rat hepatocytes[1].
Cotadutide (100 nM, 2 h) induces mitochondrial turnover and enhances mitochondrial function in mouse primary hepatocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cotadutide 相关抗体:
体内研究
(In Vivo)

Cotadutide (10?nmol/kg, s.c., once) suppresses food intake in DIO mice relative to vehicle‐treated controls[1].
Cotadutide (10 or 30?nmol/kg, s.c., once daily for 14-16 weeks) reduces body weight in DIO mice[1].
Cotadutide (30 nmol/kg, s.c., once a day for 6 weeks) reduces hepatic fibrosis and inflammation in in ob/ob AMLN NASH mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obesity (DIO) mice[1]
Dosage: 10 nmol/kg
Administration: Subcutaneousinjection (s.c.)
Result: Showed a redction of food intake in mice after an acute administration.
Animal Model: Diet-induced obesity (DIO) mice[1]
Dosage: 10 or 30 nmol/kg
Administration: Subcutaneousinjection (s.c.)
Result: Reduced body weight and food intake, and improved glucose tolerance in DIO mice.
Clinical Trial
分子量

3728.09

Formula

C167H252N42O55
CAS 号
性状

固体

颜色

White to off-white

Sequence

1'-{palmtoyl-Glu}; His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys-Ser-Glu-Tyr-Leu-Asp-Ser-Glu-Arg-Ala-Arg-Asp-Phe-Val-Ala-Trp-Leu-Glu-Ala-Gly-Gly (Amide bridge: 1'-{palmtoyl-Glu}-Lys10)
Sequence Shortening

1'-{palmtoyl-Glu}; HSQGTFTSDKSEYLDSERARDFVAWLEAGG (Amide bridge: 1'-{palmtoyl-Glu}-Lys10)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (26.82 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2682 mL 1.3412 mL 2.6823 mL
5 mM 0.0536 mL 0.2682 mL 0.5365 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Cotadutide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2682 mL 1.3412 mL 2.6823 mL 6.7058 mL
5 mM 0.0536 mL 0.2682 mL 0.5365 mL 1.3412 mL
10 mM 0.0268 mL 0.1341 mL 0.2682 mL 0.6706 mL
15 mM 0.0179 mL 0.0894 mL 0.1788 mL 0.4471 mL
20 mM 0.0134 mL 0.0671 mL 0.1341 mL 0.3353 mL
25 mM 0.0107 mL 0.0536 mL 0.1073 mL 0.2682 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cotadutide1686108-82-6MEDI0382MEDI 0382MEDI-0382GCGRGlucagon ReceptorFOODuptakediabeteT2DobesityNASHfibrosisinflammationInhibitorinhibitorinhibit

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目录号：
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