2. Metabolic Enzyme/Protease
  3. MMP
  4. CP-544439

CP-544439 是一种具有口服活性的 MMP-13 抑制剂，IC50 为 0.75 nM。

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CP-544439 Chemical Structure

CP-544439 Chemical Structure

CAS No. : 230954-09-3

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CP-544439 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM[1][2].

IC50 & Target[2] [1] [1]

MMP-13

0.75 nM (IC50)

MMP-12

0.24 nM (IC50)

MMP-1

420 nM (IC50)

MMP-2

1.6 nM (IC50)

MMP-3

16 nM (IC50)

MMP-8

1.4 nM (IC50)

MMP-9

12 nM (IC50)

MMP-14

7.4 nM (IC50)

体内研究
(In Vivo)

In vivo studies using a hamster model, in which the cartilage collagen degradation was induced by intra-articular injection of recombinant human MMP-13, demonstrated that oral administration of CP-544439 inhibits degradation of the cartilage collagen with an ED50 of 14 mg/kg and efficacious plasma concentrations ranging from 0.5 to 1.0 g/ml[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

410.42

Formula

C18H19FN2O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CP-544439 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-544439230954-09-3CP544439CP 544439MMPMatrix metalloproteinasesoralMMP-13MMP-12cartilagecollagenhamstermodelInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-107013
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