2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. CP-96,345

CP-96,345 是一种特异、高效且具有口服活性的 速激肽 (tachykinin) 和物质 P 受体非肽抑制剂。CP-96,345 可抑制 P 物质和神经激肽 A (neurokinin A) 引起的血压下降。CP-96,345 可用于神经性炎症的研究。

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CP-96,345 Chemical Structure

CP-96,345 Chemical Structure

CAS No. : 132746-60-2

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规格 价格 是否有货 数量
5 mg ￥3878
3 - 4 周
10 mg 现货 3 - 4 周
50 mg   询价  
100 mg   询价  

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CP-96,345 相关抗体

Top Publications Citing Use of Products

查看 Neurokinin Receptor 亚型特异性产品:

查看所有亚型
NK1 NK2 NK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP-96,345 is a specific, highly potent, and orally active tachykinin and substance P receptor non-peptide inhibitor. CP-96,345 prevents the drop in blood pressure evoked by substance P and neurokinin A. CP-96,345 can be used for researching neurogenic inflammation[1].

IC50 & Target

Tachykinin, Substance P receptor[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
46.83 μM
Compound: CP-96345
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 28710964]
CHO IC50
0.2 nM
Compound: 1, (CP-96345)
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
Tested against cloned human NK1 receptor by displacement of 125 I -labeled substance P expressed in CHO cells
[PMID: 8393115]
CHO IC50
0.45 nM
Compound: CP-96345
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
Binding affinity against human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
[PMID: 7535362]
CHO IC50
0.5 nM
Compound: CP-96345
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
Binding affinity against wild type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
[PMID: 7535362]
CHO IC50
22 nM
Compound: CP-96345
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
Binding affinity against Gln165Ala mutant type human Tachykinin receptor 1 expressed in CHO cells was measured by its ability to displace [125I]- Tyr-8 substance P.
[PMID: 7535362]
IM-9 IC50
0.33 nM
Compound: CP-96345
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SP
10.1016/0960-894X(96)00148-5
IM-9 IC50
0.35 nM
Compound: 1
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand
[PMID: 8576917]
IM-9 IC50
0.48 nM
Compound: 1
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligand
[PMID: 7520943]
IM-9 IC50
0.52 nM
Compound: CP-96345
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
Compound was tested in vitro for its Tachykinin receptor 1 affinity by the displacement of [125I]Bolton-Hunter substance p from human IM-9 cells
10.1016/S0960-894X(01)80246-8
IM-9 IC50
0.77 nM
Compound: 3, (CP-96345)
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligand
[PMID: 1378901]
MRC5 IC50
57.9 μM
Compound: CP-96345
Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay
Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay
[PMID: 28710964]
分子量

412.57

Formula

C28H32N2O
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (198 KB)

产品使用指南 (1538 KB)
参考文献

CP-96,345 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-96,345132746-60-2Neurokinin ReceptorNK receptorTachykinin receptorNeurogenic inflammationOrally activeBlood pressureSubstance P receptorTachykininInhibitorinhibitorinhibit

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目录号：
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