2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Nuclear Factor of activated T Cells (NFAT) NF-κB Reactive Oxygen Species
  4. CPS-11

CPS-11  (Synonyms: N-(Hydroxymethyl)thalidomide)

目录号: HY-117987 纯度: 99.39%
COA 产品使用指南

摩尔计算器

CPS-11 (N-(Hydroxymethyl)thalidomide) 是 Thalidomide (HY-14658) 类似物，是一种有效的抗癌剂 (anti-cancer agent)。CPS-11 可抑制 NF-κB，激活 NFAT，通过升高 ROS 抑制细胞因子表达。CPS-11 对 MM (多发性骨髓瘤)细胞系表现出更广泛的活性谱和更高的效力。

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CPS-11 Chemical Structure

CPS-11 Chemical Structure

CAS No. : 145945-21-7

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规格 价格 是否有货 数量
1 mg ￥2272
In-stock
5 mg ￥4545
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

CPS-11 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines[1][2][3].

体外研究
(In Vitro)

CPS-11 abrogates ability of bone marrow stromal cells (BMSCs) to induce proliferation of MM cells, confirming its ability to target tumor cells in the bone marrow microenvironment[1].
CPS-11 (0-200 μM, 0 or 4 h) shows virtually no effect on activation of p38 and only slight, transient activation of ATF2 and HSP27[2].
CPS-11 (0-100 μM, 24 or 48 h) was no toxic to H157 cells, WT MEFs or the p38α-/- MEFs at doses as high as 100 μM[2].
CPS-11 (50 μM, 24 or 48 h) does not induce apoptosis in H157 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CPS-11 相关抗体:

Western Blot Analysis[2]

Cell Line: H157 cells, PC3 cells, HUVEC cells
Concentration: 0, 1, 5, 10, 20, 50, 100 and 200 μM
Incubation Time: 0, 15 min, 30 min, 1 h, 2 h, and 4 h
Result: Showed virtually no effect on activation of p38 and only slight, transient activation of ATF2 and HSP27. Increased Akt phosphorylation within 15 minutes, and decreased Akt phosphorylation from 15 minutes to 4 hours.

Cell Cytotoxicity Assay[2]

Cell Line: H157 cells, wild-type (WT) mouse embryonic fibroblasts (MEF) and p38α-/- MEF
Concentration: 0, 20, 50, and 100 μM
Incubation Time: 24 or 48 hours
Result: Showed no toxic to H157 cells at doses as high as 100 μM and an incubation time of 48 hours. had no toxic effect on either the WT MEFs or the p38α-/- MEFs at doses as high as 100 μM.

Apoptosis Analysis[2]

Cell Line: H157 cells
Concentration: 50 μM
Incubation Time: 24 or 48 hours
Result: Did not induce apoptosis in H157 cells at either time point.
分子量

288.26

Formula

C14H12N2O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 57.7 mg/mL (200.17 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4691 mL 17.3455 mL 34.6909 mL
5 mM 0.6938 mL 3.4691 mL 6.9382 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

CPS-11 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4691 mL 17.3455 mL 34.6909 mL 86.7273 mL
5 mM 0.6938 mL 3.4691 mL 6.9382 mL 17.3455 mL
10 mM 0.3469 mL 1.7345 mL 3.4691 mL 8.6727 mL
15 mM 0.2313 mL 1.1564 mL 2.3127 mL 5.7818 mL
20 mM 0.1735 mL 0.8673 mL 1.7345 mL 4.3364 mL
25 mM 0.1388 mL 0.6938 mL 1.3876 mL 3.4691 mL
30 mM 0.1156 mL 0.5782 mL 1.1564 mL 2.8909 mL
40 mM 0.0867 mL 0.4336 mL 0.8673 mL 2.1682 mL
50 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7345 mL
60 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4455 mL
80 mM 0.0434 mL 0.2168 mL 0.4336 mL 1.0841 mL
100 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.8673 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPS-11145945-21-7N-(Hydroxymethyl)thalidomideCPS11CPS 11Nuclear Factor of activated T Cells (NFAT)NF-κBReactive Oxygen SpeciesNuclear factor-κBNuclear factor-kappaBH157 cellsPC3 cellsH1703 cellsmouse embryonic fibroblastsMEFp38bone marrow stromal cellsBMSCATF2HSP27Multiple MyelomaMMProstate cancerThalidomideInhibitorinhibitorinhibit

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