2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. CRX-526

CRX-526 是一种 TLR4 拮抗剂，可以阻断脂多糖 (LPS，HY-D1056) 与免疫系统的相互作用，包括防止 LPS 刺激的促炎基因的表达，以及阻断 LPS 引起的 TNF-α 释放。CRX-526 在两种结肠炎小鼠模型中 (即dextran sodium sulfate 诱导的结肠炎模型和多药耐药基因 1a 缺陷小鼠模型) 具有抗炎作用。

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CRX-526 Chemical Structure

CRX-526 Chemical Structure

CAS No. : 245515-64-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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CRX-526 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CRX-526 is a TLR4 antagonist that can block the interaction of lipopolysaccharide (LPS, HY-D1056) with the immune system, including preventing the expression of pro-inflammatory genes stimulated by LPS, as well as blocking the release of TNF-α induced by LPS. CRX-526 exhibits anti-inflammatory effects in two mouse models of colitis (namely, the dextran sodium sulfate-induced colitis model and the multidrug resistance gene 1a-deficient mouse model)[1].

分子量

1319.72

Formula

C69H127N2O19P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CRX-526 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRX-526245515-64-4CRX526CRX 526Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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产品名称：
CRX-526
目录号：
HY-118984
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