2. Apoptosis MAPK/ERK Pathway
  3. Apoptosis Bcl-2 Family JNK
  4. CT1-3

CT1-3 是一种有效的抗癌剂。CT1-3 通过调控 JNK/Bcl-2/Bax/XIAP 通路诱导线粒体介导的细胞凋亡 (apoptosis)。CT1-3 通过调控 E-cadherin/Snail 轴抑制人癌细胞 (HCCs) 的上皮间充质转化 (EMT) 电位，从而抑制肿瘤发生。CT1-3 在小鼠模型中表现出抗肿瘤作用，且无明显的肝、肾毒性。

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CT1-3 Chemical Structure

CT1-3 Chemical Structure

CAS No. : 2460738-32-1

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CT1-3 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CT1-3 is a potent anticancer agent. CT1-3 induces mitochondria-mediated apoptosis by regulating JNK/Bcl-2/Bax/XIAP pathway. CT1-3 suppresses the epithelial mesenchymal transition (EMT) potential of human cancer cells (HCCs) via regulating the E-cadherin/Snail axis, thus inhibits tumorigenesis. CT1-3 has a strong antitumor effect in mice model and exhibits no significant hepatic and renal toxicity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
9.07 μM
Compound: CT1-3
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
AGS IC50
8.02 μM
Compound: CT1-3
Antiproliferative activity against human AGS cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human AGS cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
HepG2 IC50
6.24 μM
Compound: CT1-3
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
HONE1 cell line IC50
14.06 μM
Compound: CT1-3
Antiproliferative activity against human HONE1 cell line assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human HONE1 cell line assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
LoVo IC50
5.1 μM
Compound: CT1-3
Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human LoVo cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
MCF7 IC50
12.72 μM
Compound: CT1-3
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
MDA-MB-231 IC50
7.48 μM
Compound: CT1-3
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
NCI-H1299 IC50
9.17 μM
Compound: CT1-3
Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
NCI-H1650 IC50
6.92 μM
Compound: CT1-3
Antiproliferative activity against human NCI-H1650 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human NCI-H1650 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
NCI-H460 IC50
6.15 μM
Compound: CT1-3
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
OVCAR-3 IC50
5.34 μM
Compound: CT1-3
Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
SGC-7901 IC50
11.47 μM
Compound: CT1-3
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
SW480 IC50
6.07 μM
Compound: CT1-3
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
U-251 IC50
7.75 μM
Compound: CT1-3
Antiproliferative activity against human U-251 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human U-251 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay
[PMID: 32416457]
体外研究
(In Vitro)

CT1-3 has excellent inhibitory activity against multiple cancer cells with IC50 range of 5.10~14.06 μM in LOVO, A549, HepG2, MDA-MB-231 and HONE1, et al[1].
CT1-3 (10 μM; 24 h) notably increases ROS production in HCCs, significantly decreases mitochondrial membrane potential, and reduces Bcl-2 and XIAP levels and increases phospho-JNK and Bax levels[1].
CT1-3 (7.5 μM; 24 h) reduces the capacity of migration and invasion of HCCs, significantly promotes the expression level of E-cadherin (E-cad), and markedly decreases the pro-metastatic and pro-invasive protein Snail[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CT1-3 相关抗体:

Western Blot Analysis[1]

Cell Line: A549, H460 and LOVO
Concentration: 10 μM
Incubation Time: 24 h
Result: Notably increased ROS production, significantly decreased mitochondrial membrane potential, and reduced Bcl-2 and XIAP levels and increased phospho-JNK and Bax levels.
体内研究
(In Vivo)

CT1-3 (20 mg/kg; IP, for 28 days) significantly suppresses tumor growth and exhibits no hepatic and renal toxicity in MDA-MB-231 xenografts model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c-nu/nu mice (injected with A549, OVCAR3 and MDA-MB-231)[1]
Dosage: 20 mg/kg
Administration: IP, for 28 days
Result: Significantly suppresses tumor growth and exhibited no hepatic and renal toxicity.
分子量

455.63

Formula

C25H29NO3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CT1-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CT1-32460738-32-1ApoptosisBcl-2 FamilyJNKc-Jun N-terminal kinaseanticancerJNK/Bcl-2/Bax/XIAP pathwaymitochondriaHCCstumorigenesisA549H460LOVOInhibitorinhibitorinhibit

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