2. Apoptosis
  3. Apoptosis TNF Receptor
  4. Cusatuzumab

Cusatuzumab  (Synonyms: 古妥珠单抗; ARGX-110)

目录号: HY-P99014 纯度: 98.80%
COA 技术支持

Cusatuzumab (ARGX-110) 是一种人 αCD70 单克隆抗体。Cusatuzumab 具有增强抗体依赖性细胞毒性 (ADCC) 的活性。 Cusatuzumab 能阻断 CD70/CD27 信号通路，减少白血病干细胞 (LSCs) 并触发与骨髓分化和凋亡 (apoptosis) 相关的基因信号。Cusatuzumab 可用于白血病的研究。

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CAS No. : 1864871-20-4

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Cusatuzumab 相关抗体

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cusatuzumab (ARGX-110) is a human αCD70 monoclonal antibody. Cusatuzumab has the activity of enhancied antibody-dependent cellular cytotoxicity (ADCC). Cusatuzumab blocks the CD70/CD27 signaling pathway, reduces leukemia stem cells (LSCs) and triggers gene signatures related to myeloid differentiation and apoptosis. Cusatuzumab can be used to study leukemia[1].

体外研究
(In Vitro)

Cusatuzumab (10 μg/mL; 14 天) 在体外能抑制白血病干细胞的集落形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cusatuzumab 相关抗体:
体内研究
(In Vivo)

Cusatuzumab (腹腔注射; 10 mg/kg; 3 次) 在 NSG 小鼠中，可降低白血病细胞定植和 LSC 数量，且在有 NK 细胞时效果更显著[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Patient bone marrow cells treated sublethally irradiated NSG mice[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.); 3 times within a week
Result: Was similarly effective in reducing leukemia cell engraftment and LSC numbers as the blocking αCD70 mAb in the absence of NK cells.
Further reduced leukemia engraftment and LSC numbers in the bone marrow and spleen in the presence of NK cells.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

古妥珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
纯度 & 产品资料

纯度: 98.80%

COA (264 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Cusatuzumab 相关分类

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Keywords:

Cusatuzumab1864871-20-4ARGX-110古妥珠单抗ARGX110ARGX 110ApoptosisTNF ReceptorTumor Necrosis Factor ReceptorTNFReukemia stem cells (LSCs)Inhibitorinhibitorinhibit

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