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  4. CWHM-1552

CWHM-1552 是一种口服有效的恶性疟原虫抑制剂，对 3D7 和 Dd2 strain 的 IC50s 分别是 51 nM and 53 nM。

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CWHM-1552 Chemical Structure

CWHM-1552 Chemical Structure

CAS No. : 2368253-58-9

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规格 价格 是否有货 数量
1 mg ￥2205
1 - 2 周
5 mg   询价  
10 mg   询价  

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CWHM-1552 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC50s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively[1].

IC50 & Target

IC50: 51 nM (3D7 strain) and 53 nM (Dd2 strain)[1]
体内研究
(In Vivo)

CWHM-1552 (Compound (-)-32a) (orally; 3-30 mg/kg/day for 4 days) inhibits parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day[1].
CWHM-1552 (i.v. administration; 2 mg/kg/day for 48 hours) has respectable half-lives (2.7 h) and low clearance in mice[1].
CWHM-1552 has good pharmacokinetic properties and oral efficacy in a mouse model of malaria. CWHM-1552 has an in vivo ED90 of <10 mg/kg/day and ED99 of 30 mg/kg/day, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P. chabaudi ASS infected Mice[1]
Dosage: 3, 10, 30 mg/kg
Administration: Orally; daily for 4 days
Result: Inhibited parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day.
Animal Model: Male KM mice[1]
Dosage: 2 mg/kg
Administration: I.v. administration; daily
Result: Had respectable half-lives (2.7 h) and low clearance in mice.
分子量

387.47

Formula

C22H27F2N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CWHM-1552 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CWHM-15522368253-58-9CWHM1552CWHM 1552ParasiteInhibitorinhibitorinhibit

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产品名称：
CWHM-1552
目录号：
HY-128354
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