2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. CXCR2 antagonist 3

CXCR2 antagonist 3 (compound 11h) 是 CXC 趋化因子受体 2 (CXCR2) 的有效拮抗剂。CXCR2 antagonist 3 对 CXCR2 表现出两位数的纳摩尔效力，并显着抑制中性粒细胞浸润到气囊中。CXCR2 antagonist 3 可减少中性粒细胞和 MDSC 的浸润，并增强 CD3+ T 淋巴细胞向 Pan02 肿瘤组织的浸润。

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CXCR2 antagonist 3 Chemical Structure

CXCR2 antagonist 3 Chemical Structure

CAS No. : 2647464-92-2

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CXCR2 antagonist 3 相关抗体

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CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BXPC-3 IC50
> 10 μM
Compound: 11h
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34676759]
MIA PaCa-2 IC50
> 10 μM
Compound: 11h
Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34676759]
PANC-1 IC50
> 10 μM
Compound: 11h
Cytotoxicity against human PanC-1 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human PanC-1 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34676759]
PBMC IC50
> 10 μM
Compound: 11h
Cytotoxicity against human PBMC cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human PBMC cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34676759]
SW1990 IC50
> 10 μM
Compound: 11h
Cytotoxicity against human SW1990 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human SW1990 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 34676759]
分子量

362.38

Formula

C17H15FN2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CXCR2 antagonist 3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CXCR2 antagonist 32647464-92-2CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXC chemokine receptorneutrophilCD3+T lymphocytesPan02 tumorInhibitorinhibitorinhibit

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CXCR2 antagonist 3
目录号：
HY-139874
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