1. Metabolic Enzyme/Protease
  2. Acyltransferase
  3. Cyano-myracrylamide

Cyano-myracrylamide 是一种锌指 DHHC 结构域含量棕榈酰转移酶 20 (zDHHC20) 的抑制剂,IC50 值为 1.35 µM。Cyano-myracrylamide 还抑制 EGFR 和 CD36 的 S -酰化。Cyano-myracrylamide 在表达重组大肠杆菌 GobX、重组人 MyD88 或内源性 Ras 的 HEK293T 细胞中还抑制了大肠杆菌 E3 连接酶 GobX、MyD88 和 Ras 的 S-酰化,这些都是 zDHHC20、zDHHC9 和 zDHHC6 的底物。

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Cyano-myracrylamide Chemical Structure

Cyano-myracrylamide Chemical Structure

CAS No. : 2801702-34-9

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生物活性

Cyano-myracrylamide is an inhibitor of zinc finger DHHC domain-containing palmitoyltransferase 20 (zDHHC20) with an IC50 value of 1.35 µM. Cyano-myracrylamide also inhibits the S-Acylation of EGFR and CD36. Cyano-myracrylamide also inhibits S-acylation of Legionella E3 ligase GobX, MyD88, and Ras, which are substrates of zDHHC20, zDHHC9, and zDHHC6, respectively, in HEK293T cells expressing recombinant Legionella GobX, recombinant human MyD88, or endogenous Ras[1].

分子量

306.49

Formula

C19H34N2O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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产品名称:
Cyano-myracrylamide
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HY-155938
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