2. Anti-infection
  3. CMV Orthopoxvirus
  4. Cyclic HPMPC

Cyclic HPMPC 是一种有效的抗病毒剂。Cyclic HPMPC 可在感染致死性牛痘苗病毒 (IHD 毒株) 小鼠中增加动脉氧饱和度水平。Cyclic HPMPC 可改善先天性豚鼠巨细胞病毒 (GPCMV) 感染的结果，减少病毒在豚鼠模型中的复制。

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Cyclic HPMPC Chemical Structure

Cyclic HPMPC Chemical Structure

CAS No. : 127757-45-3

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Cyclic HPMPC 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model[1][2].

IC50 & Target

Vaccinia virus, GPCMV[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM EC50
> 20 μg/mL
Compound: cHPMPC
Antiviral activity against HIV1 3B in CEM cells assessed as reduction of virus-induced cytopathogenicity after 4 days
Antiviral activity against HIV1 3B in CEM cells assessed as reduction of virus-induced cytopathogenicity after 4 days
[PMID: 17948980]
CCRF-CEM EC50
> 20 μg/mL
Compound: cHPMPC
Antiviral activity against HIV2 ROD in CEM cells assessed as reduction of virus-induced cytopathogenicity after 4 days
Antiviral activity against HIV2 ROD in CEM cells assessed as reduction of virus-induced cytopathogenicity after 4 days
[PMID: 17948980]
HEL CC50
≥ 76 μg/mL
Compound: cHPMPC
Cytotoxicity against HEL cells assessed as cell growth after 3 days
Cytotoxicity against HEL cells assessed as cell growth after 3 days
[PMID: 17948980]
HEL 299 CC50
335 μM
Compound: 2a, cHPMPC
Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis
Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis
[PMID: 17893157]
HEL 299 EC50
6.1 μM
Compound: 2a, cHPMPC
Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining
Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining
[PMID: 17893157]
HEL 299 EC50
8.8 μM
Compound: 2a, cHPMPC
Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining
Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining
[PMID: 17893157]
HFF IC50
> 100 μM
Compound: 4, (S)-cHPMPC
Cytotoxicity against HFF cells after 48 hrs by visual cytotoxicity observation assay
Cytotoxicity against HFF cells after 48 hrs by visual cytotoxicity observation assay
[PMID: 21812420]
HFF IC50
0.25 μM
Compound: 4, (S)-cHPMPC
Antiviral activity against HCMV Towne infected in HFF cells incubated for 10 days by plaque reduction assay
Antiviral activity against HCMV Towne infected in HFF cells incubated for 10 days by plaque reduction assay
[PMID: 21812420]
HFF IC50
0.25 μM
Compound: 2, cHPMPC
Antiviral activity against Human cytomegalovirus Towne infected in HFF cells assessed as reduction in plaque formation after 10 days
Antiviral activity against Human cytomegalovirus Towne infected in HFF cells assessed as reduction in plaque formation after 10 days
[PMID: 21641218]
HFF IC50
30 μM
Compound: 4, (S)-cHPMPC
Antiviral activity against Cowpox virus Brighton infected in HFF cells incubated for 3 days by plaque reduction assay
Antiviral activity against Cowpox virus Brighton infected in HFF cells incubated for 3 days by plaque reduction assay
[PMID: 21812420]
HFF IC50
30 μM
Compound: 2, cHPMPC
Antiviral activity against Cowpox virus Brighton infected in HFF cells assessed as reduction in plaque formation after 3 days
Antiviral activity against Cowpox virus Brighton infected in HFF cells assessed as reduction in plaque formation after 3 days
[PMID: 21641218]
HFF IC50
40 μM
Compound: 4, (S)-cHPMPC
Antiviral activity against Vaccinia virus Copenhagen infected in HFF cells incubated for 3 days by plaque reduction assay
Antiviral activity against Vaccinia virus Copenhagen infected in HFF cells incubated for 3 days by plaque reduction assay
[PMID: 21812420]
HFF IC50
40 μM
Compound: 2, cHPMPC
Antiviral activity against Vaccinia virus Copenhagen infected in HFF cells assessed as reduction in plaque formation after 3 days
Antiviral activity against Vaccinia virus Copenhagen infected in HFF cells assessed as reduction in plaque formation after 3 days
[PMID: 21641218]
HFF IC50
50 μM
Compound: 4, (S)-cHPMPC
Antiviral activity against HSV1 KOS infected in HFF cells incubated for 3 days by plaque reduction assay
Antiviral activity against HSV1 KOS infected in HFF cells incubated for 3 days by plaque reduction assay
[PMID: 21812420]
KB IC50
> 100 μM
Compound: 4, (S)-cHPMPC
Cytotoxicity against human KB cells after 48 hrs by crystal violet staining based spectrophotometric analysis
Cytotoxicity against human KB cells after 48 hrs by crystal violet staining based spectrophotometric analysis
[PMID: 21812420]
KB CC50
> 100 μM
Compound: 2, cHPMPC
Cytotoxicity against human KB cells after 48 hrs by crystal violet staining technique
Cytotoxicity against human KB cells after 48 hrs by crystal violet staining technique
[PMID: 21641218]
Vero EC50
> 200 μg/mL
Compound: cHPMPC
Antiviral activity against Parainfluenza 3 in Vero cells reduction of virus-induced cytopathogenicity after 4 days
Antiviral activity against Parainfluenza 3 in Vero cells reduction of virus-induced cytopathogenicity after 4 days
[PMID: 17948980]
Vero EC50
> 200 μg/mL
Compound: cHPMPC
Antiviral activity against Reovirus 1 in Vero cells reduction of virus-induced cytopathogenicity after 4 days
Antiviral activity against Reovirus 1 in Vero cells reduction of virus-induced cytopathogenicity after 4 days
[PMID: 17948980]
Vero EC50
> 200 μg/mL
Compound: cHPMPC
Antiviral activity against Sindbis virus in Vero cells reduction of virus-induced cytopathogenicity after 4 days
Antiviral activity against Sindbis virus in Vero cells reduction of virus-induced cytopathogenicity after 4 days
[PMID: 17948980]
Vero EC50
> 200 μg/mL
Compound: cHPMPC
Antiviral activity against Punta Toro virus in Vero cells reduction of virus-induced cytopathogenicity after 4 days
Antiviral activity against Punta Toro virus in Vero cells reduction of virus-induced cytopathogenicity after 4 days
[PMID: 17948980]
分子量

261.17

Formula

C8H12N3O5P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cyclic HPMPC 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic HPMPC127757-45-3CMVOrthopoxvirusCytomegalovirusAntiviralVaccinia virusguinea pigsmallpoxInhibitorinhibitorinhibit

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