2. 多肽产品
  3. 多肽及其衍生物
  4. 多肽药物递送 激素肽与神经肽 抑制剂与底物肽 药物肽
  5. 靶向肽
  6. Cyclic somatostatin

Cyclic somatostatin  (Synonyms: 环状生长激素抑制素; SRIF-14; Somatostatin-14)

目录号: HY-P0084 纯度: 99.77%
COA 产品使用指南

摩尔计算器

Cyclic somatostatin (SRIF-14) 是一种生长激素释放抑制因子，用于研究严重急性胃十二指肠溃疡出血。Cyclic somatostatin 是一种与乙酰胆碱共存储于心脏副交感神经支配的神经肽，直接影响心室心肌细胞的收缩。Cyclic somatostatin 抑制异丙肾上腺素的收缩反应，IC50 值为 13 nM。Cyclic somatostatin 可用于心血管疾病的研究。

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Custom Peptide Synthesis

Cyclic somatostatin Chemical Structure

Cyclic somatostatin Chemical Structure

CAS No. : 38916-34-6

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规格 价格 是否有货 数量
1 mg ￥200
In-stock
5 mg ￥320
In-stock
10 mg ￥450
In-stock
25 mg ￥750
In-stock
50 mg ￥990
In-stock
100 mg ￥1480
In-stock
500 mg ￥3713
In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Cyclic somatostatin:

Cyclic somatostatin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease[1][2][3].

IC50 & Target

IC50: 13 nM (contractile response of isoprenaline)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
AtT20 IC50
7.4 x 10-11 M
Compound: Somatostatin-14
Displacement of [125I]Tyr11-somatostatin-14 from Sst receptor in mouse AtT-20 cells measured after 60 mins by scintillation counting method
Displacement of [125I]Tyr11-somatostatin-14 from Sst receptor in mouse AtT-20 cells measured after 60 mins by scintillation counting method
[PMID: 27876250]
CHO IC50
1.6 nM
Compound: 1, Somatostatin, SRIF
Displacement of 125I-[LTT]-SRIF-28 from human sst1 receptor in CHO cells after 2 hrs by autoradiography
Displacement of 125I-[LTT]-SRIF-28 from human sst1 receptor in CHO cells after 2 hrs by autoradiography
[PMID: 21806016]
CHO IC50
1.9 nM
Compound: SS14
Displacement of [125I]-[LTT]-SS28 from human SST1 receptor expressed in CHO cells after 2 hrs by autoradiographic analysis
Displacement of [125I]-[LTT]-SS28 from human SST1 receptor expressed in CHO cells after 2 hrs by autoradiographic analysis
[PMID: 24378707]
HEK293 IC50
4.2 nM
Compound: SS14
Displacement of [125I]-[LTT]-SS28 from human SST5 receptor expressed in HEK293 cells after 2 hrs by autoradiographic analysis
Displacement of [125I]-[LTT]-SS28 from human SST5 receptor expressed in HEK293 cells after 2 hrs by autoradiographic analysis
[PMID: 24378707]
HEK293 IC50
4.2 nM
Compound: 1, Somatostatin, SRIF
Displacement of 125I-[LTT]-SRIF-28 from human sst5 receptor in HEK293 cells after 2 hrs by autoradiography
Displacement of 125I-[LTT]-SRIF-28 from human sst5 receptor in HEK293 cells after 2 hrs by autoradiography
[PMID: 21806016]
体外研究
(In Vitro)

Cyclic somatostatin (0-10 μM; 15 min) dose-dependently inhibits the contractile response to isoprenaline in rat ventricular cardiomyocytes with an IC50 value of 13 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclic somatostatin 相关抗体:
体内研究
(In Vivo)

Cyclic somatostatin (5 μg/kg; i.v. per hour once for 18-22 hours) affects visceral metabolism in ruminants[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Polypay sheeps[3]
Dosage: 5 μg/kg
Administration: Intravenous injection; 5 μg/kg per hour once; for 18-22 hours
Result: Decreased net portal-drained viscera release of glucose, a-amino N, ammonia N, b-hydrox ybutyrate, oxygen consumption, liver oxygen consumption, and total splanchnic a-amino N release and oxygen consumption. Increased lactate release and net hepatic glucose output.
分子量

1637.88

Formula

C76H104N18O19S2
CAS 号
性状

固体

颜色

White to off-white

Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge: Cys3-Cys14)
Sequence Shortening

AGCKNFFWKTFTSC (Disulfide bridge: Cys3-Cys14)
中文名称

环状生长激素抑制素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (61.05 mM; 超声助溶)

DMF 中的溶解度 : 100 mg/mL (61.05 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6105 mL 3.0527 mL 6.1055 mL
5 mM 0.1221 mL 0.6105 mL 1.2211 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.77%

COA (307 KB) LCMS (293 KB) 元素分析报告 (231 KB)

产品使用指南 (1538 KB)
参考文献

Cyclic somatostatin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMF 1 mM 0.6105 mL 3.0527 mL 6.1055 mL 15.2636 mL
5 mM 0.1221 mL 0.6105 mL 1.2211 mL 3.0527 mL
10 mM 0.0611 mL 0.3053 mL 0.6105 mL 1.5264 mL
15 mM 0.0407 mL 0.2035 mL 0.4070 mL 1.0176 mL
20 mM 0.0305 mL 0.1526 mL 0.3053 mL 0.7632 mL
25 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.6105 mL
30 mM 0.0204 mL 0.1018 mL 0.2035 mL 0.5088 mL
40 mM 0.0153 mL 0.0763 mL 0.1526 mL 0.3816 mL
50 mM 0.0122 mL 0.0611 mL 0.1221 mL 0.3053 mL
60 mM 0.0102 mL 0.0509 mL 0.1018 mL 0.2544 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic somatostatin38916-34-6SRIF-14 Somatostatin-14环状生长激素抑制素SRIF14SRIF 14Somatostatin14Somatostatin 14Somatostatin-14Othersgrowth hormonegastroduodenal ulcerneuropeptidecardiomyocytetetradecapeptidesheepmetabolismruminantInhibitorinhibitorinhibit

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