2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  3. HIF/HIF Prolyl-Hydroxylase VEGFR
  4. cyclo(CLLFVY)

cyclo(CLLFVY) 是缺氧诱导因子-1 (HIF-1) 的抑制剂，IC50 为 19 μM (在 U2OS 中) 和 16 μM (在 MCF-7 中)。cyclo(CLLFVY) 与 HIF-1α 的 PAS-B 结构域结合，抑制 HIF-1 二聚化和转录活性。cyclo(CLLFVY) 下调缺氧反应基因 (如 VEGF 和 CAIX) 的表达，对 HIF-1 相关癌症表现出抗肿瘤作用。

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cyclo(CLLFVY) Chemical Structure

cyclo(CLLFVY) Chemical Structure

CAS No. : 1446322-73-1

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cyclo(CLLFVY) 相关抗体

Top Publications Citing Use of Products

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

查看 VEGFR 亚型特异性产品:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers[1].

分子量

738.94

Formula

C38H54N6O7S
CAS 号
Sequence

cyclo(Cys-Leu-Leu-Phe-Val-Tyr)
Sequence Shortening

cyclo(CLLFVY)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

cyclo(CLLFVY) 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cyclo(CLLFVY)1446322-73-1HIF/HIF Prolyl-HydroxylaseVEGFRHypoxia-inducible factorsHIFsHIF-PHVascular endothelial growth factor receptorU2OSMCF-7Inhibitorinhibitorinhibit

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