2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. CYD-2-11

CYD-2-11 是一种选择性的 Bax 激动剂，Ki 值为 34.1 nM。CYD-2-11 诱导细胞凋亡，对 MDA-MB-231 和 MCF-7 乳腺癌细胞系具有抗增殖作用，IC50 值为 3.22 和 3.81 μM。CYD-2-11 在 MDA-MB-231 肿瘤模型中抑制肿瘤生长。CYD-2-11 可用于乳腺癌和肺癌的研究。

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CYD-2-11 Chemical Structure

CYD-2-11 Chemical Structure

CAS No. : 1425944-22-4

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CYD-2-11 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CYD-2-11 is a selective Bax agonist with a Ki value of 34.1 nM. CYD-2-11 induces cell apoptosis and shows antiproliferative activity to breast cancer MDA-MB-231 and MCF-7 cell lines with IC50 values of 3.22 and 3.81 μM, respectively. CYD-2-11 suppresses tumor growth in MDA-MB-231 tumor models. CYD-2-11 can be used for the research of breast and lung cancer[1][2].

体外研究
(In Vitro)

CYD-2-11 (0-100 μM; 48 h) shows anti-proliferation effects to breast cancer cells[1].
CYD-2-11 (5 μM; 48 h) selectively binds to Bax protein and induces apoptosis in NSCLC and SCLC cell lines[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CYD-2-11 相关抗体:

Cell Proliferation Assay[1]

Cell Line: T47D, MCF-7, MDA-MB-231, MDA-MB-468 and MCF-10A cell lines
Concentration: 0.01, 0.1, 1, 5, 10 and 100 µM
Incubation Time: 48 hours
Result: Inhibited cell proliferation of T47D, MCF-7, MDA-MB-231, MDA-MB-468 and MCF-10A cells with IC50 values of 4.37, 9.47, 3.81, 3.22 and 8.73 μM, respectively.

Apoptosis Analysis[2]

Cell Line: SCLC and NSCLC cell lines
Concentration: 5 µM
Incubation Time: 48 hours
Result: Induced cell apoptosis in both SCLC and NSCLC cells with a higher effect than SMBA1.
体内研究
(In Vivo)

CYD-2-11 (20 mg/kg; i.p.; once daily for 7 days) inhibits tumor growth[1].
CYD-2-11 (40 mg/kg; i.p.; once daily for 14 days) represses lung cancer growth and overcomes rapalog resistance with the combination of RAD001 (1 mg/kg) in murine lung cancer models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice with MDA-MB-231 tumor xenografts[1]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; 20 mg/kg; once daily for 7 days
Result: Exhibited a 57% inhibition rate of MDA-MB-231 tumor growth in vivo.
分子量

358.39

Formula

C22H18N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CYD-2-11 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

CYD-2-111425944-22-4Bcl-2 FamilyApoptosisER-positivetriple-negativebreast cancerSMBA1apoptosisanti-proliferationSCLCNSCLCmurine lung cancerRAD001miceInhibitorinhibitorinhibit

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产品名称：
CYD-2-11
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HY-120275
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