2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. CYD-4-61

CYD-4-61 是一种用于乳腺癌研究的新型 Bax 激活剂。CYD-4-61 抑制三阴性乳腺癌 MDA-MB-231 和 ER 阳性乳腺癌 MCF-7 细胞系增殖。CYD-4-61 激活 Bax 蛋白诱导细胞色素 c 释放，调节凋亡生物标志物，导致癌细胞凋亡 (apoptosis)。

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CYD-4-61 Chemical Structure

CYD-4-61 Chemical Structure

CAS No. : 1425944-33-7

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CYD-4-61 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CYD-4-61 is a novel Bax activator used for breast cancer research. CYD-4-61 inhibits triple-negative breast cancer MDA-MB-231 and ER-positive breast cancer MCF-7 cell lines proliferation. CYD-4-61 activates Bax protein to induce cytochrome c release and regulate apoptotic biomarkers, leading to cancer cell apoptosis[1].

IC50 & Target[1]

Bax

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF-10A IC50
0.11 μM
Compound: CYD-4-61
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell viability after 72 hrs by MTT assay
[PMID: 33845235]
MCF7 IC50
0.06 μM
Compound: CYD-4-61
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
[PMID: 33845235]
MDA-MB-231 IC50
0.07 μM
Compound: CYD-4-61
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability after 72 hrs by MTT assay
[PMID: 33845235]
体外研究
(In Vitro)

CYD-4-61 (compound 49) (0-10 μM; 72 h) exhibits significantly improved antiproliferative activity with IC50s of 0.07 µM against triple-negative breast cancer MDA-MB-231 and 0.06 µM against ER-positive breast cancer MCF-7 cell lines, respectively[1].
CYD-4-61 (1 μM; 72 h) induces apoptosis among MCF-7 and MDA-MB-231 cells[1].
CYD-4-61 (5 μM and 10 μM; ) increases the level of cells with apoptotic bodies in MDA-MB-231 and MCF-7 cells[1].
CYD-4-61 (5 μM; 0-48 h) decreases the level of p-Bax, but increases the levle of total Bax protein, cytochrome c, and several protein markers related to apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CYD-4-61 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-10A, T47D, MCF-7, MDA-MB-231, and MDA-MB-468 cells
Concentration: 0.1, 1, and 10 μM
Incubation Time: 72 hours
Result: Inhibited triple-negative breast cancer MDA-MB-231 and ER-positive breast cancer MCF-7 cell lines proliferation and viability.

Western Blot Analysis[1]

Cell Line: MCF-7 and MDA-MB-231 cells
Concentration: 5 μM
Incubation Time: 0, 6, 12, 24, and 48 hours
Result: Dose-dependently led to the upregulation of cleaved PARP-1, cleaved caspase 3, and downregulation of cyclin D1.
体内研究
(In Vivo)

CYD-4-61 (2.5 mg/kg; i.p.; once daily for 7 d) inhibits triple-negative breast tumor growth in xenograft model in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Triple-negative breast cancer MDA-MB-231 xenograft model in mice[1]
Dosage: 2.5 mg/kg
Administration: Intraperitoneal injection; once daily for 7 consecutive days
Result: Significantly suppressed the growth of MDA-MB-231 tumors with an inhibition rate of 55%.
分子量

359.38

Formula

C21H17N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CYD-4-61 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYD-4-611425944-33-7Bcl-2 FamilyApoptosistriple-negative breast cancer MDA-MB-231ER-positive breast cancer MCF-7 cellcytochrome cInhibitorinhibitorinhibit

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目录号：
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