Cymarin  (Synonyms: 毒毛旋花苷K)

Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K⁺ release (IC₅₀=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant^[1][2][3][4].

Cymarin (0.25-1 μM) 通过阻断 IRES 定向翻译来抑制 PAX6 表达，浓度为 1 μM 时可以抑制 47.8% 的 MCF-7 细胞增殖^[2]。
Cymarin 下调 UGT1A10 表达，在细胞系 SW1990 中消除 TRA-1-60 (IC₅₀ 为 15.2 nM) 和 TRA-1-81 细胞 (IC₅₀ 为 5.1 nM)，抑制胰腺癌细胞 SW1990 和 SW1990GR 的增殖活性和细胞活力 (IC₅₀ 分别为 33.8 nM 和 40.8 nM)^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cymarin 抑制 Trichoplusia ni 幼虫的生长，EC₅₀ 值为 157 p.p.m，表现出对 Trichoplusia ni 幼虫的拒食作用，DC₅₀ 为 10.8 μg/cm^2[3]。
Cymarin (2 mg/kg，腹腔注射，每周两次，共三周) 抑制 SW1990 异种移植裸鼠的肿瘤生长，消除 TRA-1-60 细胞并降低化疗耐药性^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

548.66

C₃₀H₄₄O₉

508-77-0

固体

White to off-white

毒毛旋花苷K

Room temperature in continental US; may vary elsewhere.

• [1]. Ozaki H, et al. Interaction of palytoxin and cardiac glycosides on erythrocyte membrane and (Na+ + K+) ATPase. Eur J Biochem. 1985;152(2):475-480.  [Content Brief]

  [2]. Li Q, et al., Translation of paired box 6 (PAX6) mRNA is IRES-mediated and inhibited by cymarin in breast cancer cells. Genes Genet Syst. 2023 Oct 24;98(4):161-169.  [Content Brief]

  [3]. Akhtar Y, et al., Comparative growth inhibitory and antifeedant effects of plant extracts and pure allelochemicals on four phytophagous insect species. J Applied Entomology. 10 February 2004.128,32-38.

  [4]. Tan L, et al., A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells. J Mol Cell Biol. 2023 Nov 27;15(6):mjad039.  [Content Brief]