2. Others
  3. Amino Acid Derivatives
  4. CyPep-1

CyPep-1 是一种新型阳离子溶解肽，具有抗肿瘤活性。CyPep-1 通过与癌细胞带负电的细胞膜相互作用发挥强细胞毒性。CyPep-1 在体内外对癌细胞均表现出较强的细胞溶解活性，可用于实体瘤的研究。

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Custom Peptide Synthesis

CyPep-1 Chemical Structure

CyPep-1 Chemical Structure

CAS No. : 1319804-91-5

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Customer Review

CyPep-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CyPep-1 is a novel cationic lytic peptide with antitumor activity. CyPep-1 is highly cytotoxic by interacting with the negatively charged cell membrane of cancer cells. CyPep-1 has strong cytolytic activity on cancer cells both in vivo and in vitro, and can be used in the study of solid tumors[1].

体外研究
(In Vitro)

CyPep-1 (0-40 μg/mL；15-360 分钟) 以剂量和时间依赖的方式对肿瘤细胞系产生毒性，对正常细胞系影响较小[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CyPep-1 相关抗体:
体内研究
(In Vivo)

CyPep-1 (瘤内注射；1200 µg；单剂量) 在乳腺癌小鼠模型中具有抗肿瘤的作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4T1 murine metastatic breast cancer cells treated female BALB/c mice (average age 12625 days; average weight 23.8g)[1]
Dosage: 1200 µg
Administration: Intratumoural injection; single dose
Result: Did not cause any signs of discomfort, pain or toxicity.
Significantly reduced tumour growth and caused massive necrosis of the tumours.
Prolonged the median survival time of mice.
分子量

3451.09

Formula

C152H265N57O35
CAS 号
Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Lys-Thr-Leu-Arg-Val-Ala-Lys-Ala-Ile-Tyr-Lys-Arg-Tyr-Ile-Glu
Sequence Shortening

YGRKKRRQRRRGKTLRVAKAIYKRYIE
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CyPep-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CyPep-11319804-91-5CyPep1CyPep 1Amino Acid DerivativesBreast cancer modelosteosarcoma cellsglioma cellsInhibitorinhibitorinhibit

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目录号：
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