[D-Arg25]-Neuropeptide Y (human) 

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y₁ receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity^[1].

[D-Arg25]-NPY (1 μM) reversibly hyperpolarizes the membrane potential of hypocretin cells by 9.9 ± 1.4 mV (data not shown; p < 0.01; n = 10^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Intracerebroventricular (icv) administration of [D-Arg25]NPY stimulates food intake in freely-feeding rats^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4271.68

C₁₈₉H₂₈₅N₅₅O₅₇S

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-{d-Arg}-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2

YPSKPDNPGEDAPAEDMARYYSAL-{d-Arg}-HYINLITRQRY-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kilian Kuhn, et al. Molecular Tools for the NPY Y4 Receptor Derived from the C-Terminus of hPP and from Argininamide-type Y1R Antagonists. zur Erlangung des Doktorgrades der Naturwissenschaften an der Fakultät für Chemie und Pharmazie der Universität Regensburg.

  [2]. Li-Ying Fu, et al. Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system. J Neurosci. 2004 Oct 6;24(40):8741-51.  [Content Brief]

  [3]. Ambikaipakan Balasubramaniam, et al. Neuropeptide Y (NPY) family of hormones: progress in the development of receptor selective agonists and antagonists. Curr Pharm Des. 2003;9(15):1165-75.  [Content Brief]