2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. [D-Pro2,D-Trp7,9] Substance P

[D-Pro2,D-Trp7,9] Substance P，是 Substance P (HY-P0201) 的类似物，是一种弱激动剂，是一种有效的、特异性、竞争性的 Substance P 拮抗剂。

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Custom Peptide Synthesis

[D-Pro2,D-Trp7,9] Substance P Chemical Structure

[D-Pro2,D-Trp7,9] Substance P Chemical Structure

CAS No. : 80434-86-2

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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[D-Pro2,D-Trp7,9] Substance P 相关抗体

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NK1 NK2 NK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

[D-Pro2,D-Trp7,9] Substance P, a Substance P (HY-P0201) analogue, is a weak agonist and a potent, specific, competitive Substance P antagonist[1][2].

体外研究
(In Vitro)

[D-Pro2,D-Trp7,9] Substance P decreases proliferation only in a few cell lines, and only in the highest concentration (100 µM). [D-Pro2,D-Trp7,9] Substance P displays a significantly weaker antiproliferative action than Aprepitant (HY-10052) on cancer or normal cell lines[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

[D-Pro2,D-Trp7,9] Substance P 相关抗体:
体内研究
(In Vivo)

[D-Pro2,D-Trp7,9] Substance P (0-30 nmol, Intravitreal injection) greatly reduces not only the effects of exogenous Substance P (HY-P0201) but also the inflammatory response to trauma to the eye[1].
[D-Pro2,D-Trp7,9] Substance P specifically antagonizes the contractile effects of Substance P on the guinea-pig isolated taenia coli[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult pigmented rabbits (1.5-3 kg)[1]
Dosage: 0.03, 0.3, 3, and 30 nmol
Administration: Intravitreal injection or topical application onto the eye, 60 μL
Result: Reduced the inflammatory response to Substance P. Dependently reduced the inflammatory response to infrared irradiation. In itself, intravitreal injection of low doses of [D-Pro2, D-Trp7'9]SP had no effects on the eye.
分子量

1515.82

Formula

C74H106N20O13S
CAS 号
Sequence Shortening

RPKPQQWFWLM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

[D-Pro2,D-Trp7,9] Substance P 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[D-Pro2,D-Trp7,9] Substance P80434-86-2Neurokinin ReceptorNK receptorTachykinin receptorSubstance Paprepitant[D-Pro2D-Trp7,9]-Substance Pneurokinin-1 receptorantiproliferative effectMeW164MeW155MeW151E14 T24FIW180Fib9FIWp95Inhibitorinhibitorinhibit

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