2. Anti-infection
  3. Bacterial
  4. D13-9001

D13-9001 是 AcrB (AcrAB-TolC 外排泵亚单位) 和 MexB (MexAB-OprM 外排泵亚单位) 抑制剂，在大肠杆菌和铜绿假单胞菌中对应的 KD 值分别为 1.15 μM 和 3.57 μM。D13-9001 具有抗生素的活性。

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D13-9001 Chemical Structure

D13-9001 Chemical Structure

CAS No. : 957471-96-4

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规格 价格 是否有货 数量
5 mg ￥9944
10 - 12 周
10 mg   询价  
50 mg   询价  

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Customer Review

D13-9001 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

D13-9001 is a potent AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor with the KD values of 1.15 μM and 3.57 μM in E. coli and P. aeruginosa, respectively[1]. D13-9001 exhibits antibiotic activities[2].

IC50 & Target

KD: 1.15 μM (AcrB), 3.57 μM (MexB)[1]
体外研究
(In Vitro)

D13-9001 exhibits high solubility and a good safety profile[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

D13-9001 相关抗体:
体内研究
(In Vivo)

D13-9001 (1.25-20 mg/kg; intravenous drip infusion; 2 hours) with aztreonam (AZT) gives improved survival rates in a lethal pneumonia rats at the end of day seven compared with AZT treated alone[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats (Pulmonary infection by P. aeruginosa PAM1020)[3]
Dosage: 1.25 mg/kg, 5 mg/kg, 20 mg/kg
Administration: Intravenous drip infusion; 2 hours
Result: The combination of 1.25, 5, and 20 mg/kg of D13-9001 with 1000 mg/kg of AZT gave improved survival rates at the end of day seven, whereas no obvious effect was observed on treatment with AZT alone.
分子量

693.78

Formula

C31H39N11O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

D13-9001 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D13-9001957471-96-4BacterialInhibitorinhibitorinhibit

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产品名称：
D13-9001
目录号：
HY-124819
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