2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. DA-6886 monohydrochloride

DA-6886 是一种 5-羟色胺受体 4 (5-HT4) 激动剂。DA-6886 以 5-HT4 受体拮抗剂敏感的方式诱导大鼠食道制剂松弛。在表达 hERG 通道的 CHO 细胞中对 DA-6886 进行的评估显示，DA-6886 抑制 hERG 通道电流的 pIC50 值为 4.3，表明该化合物对 5-HT4 受体的选择性比 hERG 通道高 1000 倍。DA-6886 可用于便秘型肠易激综合征的研究。

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DA-6886 monohydrochloride Chemical Structure

DA-6886 monohydrochloride Chemical Structure

CAS No. : 1645260-76-9

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DA-6886 monohydrochloride 相关抗体

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生物活性

DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC50 value of 4.3, indicating that the compound is 1000-fold more selective for the 5-HT4 receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome[1][2].

IC50 & Target

5-HT4 Receptor

4.3 (pIC50)

分子量

443.37

Formula

C19H28Cl2N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DA-6886 monohydrochloride 相关分类

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Keywords:

DA-6886 monohydrochloride1645260-76-95-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorGPCR/G ProteinNeuroscienceSelectiveIrritable Bowel SyndromeInhibitorinhibitorinhibit

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