Daratumumab  (Synonyms: 达雷木单抗; Anti-Human CD38, Human Antibody)

Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition^[1][2].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

Daratumumab（抗人 CD38）在表达 CD38 的淋巴瘤和 MM 衍生细胞系中诱导强效的 Ab 依赖性细胞毒性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Daratumumab（ip；0.5 mg/kg；用 Daudi-luc 细胞攻击后 14 天）可抑制小鼠异种移植肿瘤模型中表达 CD38 的肿瘤细胞的生长^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

945721-28-8

液体

Colorless to light yellow

达雷妥尤单抗； 达妥木单抗； 达雷妥尤单抗

Please store the product under the recommended conditions in the Certificate of Analysis.

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  Human IgG1 kappa

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  Flow cytometry analysis of Raji cells labelling CD38 with Daratumumab at 100nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
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  Daratumumab has a significant CDC effect on Raji cells in a dose-dependent manner. The EC₅₀ for this effect is 96.2 and 98.6 ng/mL.

• [1]. Ghose J, Viola D, et al. Daratumumab induces CD38 internalization and impairs myeloma cell adhesion. Oncoimmunology. 2018;7(10):e1486948. Published 2018 Jul 23.  [Content Brief]

  [2]. de Weers M, et al. Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors. J Immunol. 2011;186(3):1840-1848.  [Content Brief]