2. Immunology/Inflammation Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. TROP2 Antibody-Drug Conjugates (ADCs) Topoisomerase
  4. Datopotamab deruxtecan

Datopotamab deruxtecan  (Synonyms: DS-1062; Dato-DXd)

目录号: HY-141598 纯度: 99.54%
COA 产品使用指南 技术支持

Datopotamab deruxtecan (DS-1062; Dato-DXd) 是一种滋养层细胞表面抗原 2 (TROP2) 导向的抗体活性分子偶联物 (ADC)。Datopotamab deruxtecan 具有强大的抗肿瘤活性。

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Datopotamab deruxtecan Chemical Structure

Datopotamab deruxtecan Chemical Structure

CAS No. : 2238831-60-0

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规格 价格 是否有货 数量
1 mg ￥12800
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Datopotamab deruxtecan 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Datopotamab deruxtecan (DS-1062; Dato-DXd) is a trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugate (ADC). Datopotamab deruxtecan has a potent antitumor activity[1].

IC50 & Target[1]

Topoisomerase I

 

体外研究
(In Vitro)

Datopotamab deruxtecan (Dato-DXd) (100 μg/mL) 特异性结合 TROP2 并被内化到肿瘤细胞中，随后在细胞内运输至溶酶体并释放 Deruxtecan，从而在体外诱导表达 TROP2 的肿瘤细胞的 DNA 损伤和凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Datopotamab deruxtecan 相关抗体:
体内研究
(In Vivo)

Datopotamab deruxtecan (Dato-DXd) (6 mg/kg) 在几种表达 TROP2 的异种移植肿瘤 (包括 NSCLC 患者来源的异种移植 (PDX) 模型) 中表现出强效抗肿瘤活性，可使肿瘤消退。Datopotamab deruxtecan 在大鼠和食蟹猴中的安全性是可接受的[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

149000 (average)

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

-80°C, protect from light
纯度 & 产品资料

纯度: 99.54%

COA (266 KB) Others (207 KB) SEC-HPLC (197 KB)

产品使用指南 (1538 KB)
参考文献

Datopotamab deruxtecan 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Datopotamab deruxtecan2238831-60-0DS-1062 Dato-DXdDS1062DS 1062TROP2Antibody-Drug Conjugates (ADCs)TopoisomeraseEGP-1M1S1GA733-1Antibody-Drug ConjugatesADCantitumorDeruxtecan,Inhibitorinhibitorinhibit

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目录号：
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