2. Epigenetics
  3. Epigenetic Reader Domain
  4. DC-BPi-11

DC-BPi-11 是溴域 PHD 指转录因子 (BPTF) 的抑制剂，IC50 为 698 nM。DC-BPi-11 对白血病细胞增殖有显著抑制作用。

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DC-BPi-11 Chemical Structure

DC-BPi-11 Chemical Structure

CAS No. : 2758411-61-7

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DC-BPi-11 的其他形式现货产品:

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DC-BPi-11 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation[1].

IC50 & Target

698 nM (BPTF)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MV4-11 IC50
0.89 μM
Compound: DC-BPi-11
Antiproliferative activity against human MC4-11 cells assessed as reduction in cell viability after 5 days by Celltiter-Glo assay
Antiproliferative activity against human MC4-11 cells assessed as reduction in cell viability after 5 days by Celltiter-Glo assay
[PMID: 34375106]
体外研究
(In Vitro)

DC-BPi-11 (0.1 nM-1 μM; 24 h) inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM[1].
DC-BPi-11 (0.01 μM-100 μM; 24 h) significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM), and (2.5-20 μM; 24 h) decreases downstream oncogene expression[1].
DC-BPi-11 (0.6-50 μM; 24 h) dose-dependently decreases c-Myc protein level[1].
DC-BPi-11 is safety and shows minimal effects on normal cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DC-BPi-11 相关抗体:

Western Blot Analysis[1]

Cell Line: Human leukemia MV-4-11 cells
Concentration: 0.6 μM, 1.8 μM, 5.6 μM, 16.6 μM, and 50 μM
Incubation Time: 24 hours
Result: Resulted depletion of c-Myc in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: Human leukemia MV-4-11 cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time: 24 hours
Result: Induced cell apoptosis by arresting cell cycle at G1 phase.
分子量

397.49

Formula

C20H23N5O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DC-BPi-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DC-BPi-112758411-61-7Epigenetic Reader DomainInhibitorinhibitorinhibit

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产品名称：
DC-BPi-11
目录号：
HY-141703
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