2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. DC44SMe

DC44SMe 是 DNA 烷化剂的磷酸盐前体，可用于合成抗体偶联活性分子 (ADC)。DC44SMe 对 Ramos，Namalwa 和 HL60/s 癌细胞的 IC50 值分别为 2.0 nM, 2.8 nM, 和 1.9 nM。DC44SMe 可用于靶向癌症研究。

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DC44SMe Chemical Structure

DC44SMe Chemical Structure

CAS No. : 1354787-76-0

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DC44SMe 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DC44SMe, a phosphate proagent of cytotoxic DNA alkylator DC44, can be used in the synthesis of antibody-drug conjugate (ADC). DC44SMe exhibits IC50s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC44SMe can be used for the targeted treatment of cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
COLO 205 IC50
> 3000 pM
Compound: 39, DC44SMe
Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human COLO205 cells assessed as cell survival after 72 hrs by clonogenic assay
[PMID: 22148292]
HL-60 IC50
1900 pM
Compound: 39, DC44SMe
Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human HL60 cells assessed as cell survival after 72 hrs by clonogenic assay
[PMID: 22148292]
NAMALVA IC50
25 pM
Compound: 39, DC44SMe
Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs in presence of bovine alkaline phosphatase by clonogenic assay
Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs in presence of bovine alkaline phosphatase by clonogenic assay
[PMID: 22148292]
NAMALVA IC50
2800 pM
Compound: 39, DC44SMe
Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human NAMALWA cells assessed as cell survival after 72 hrs by clonogenic assay
[PMID: 22148292]
Ramos IC50
2000 pM
Compound: 39, DC44SMe
Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay
Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs by clonogenic assay
[PMID: 22148292]
Ramos IC50
90 pM
Compound: 39, DC44SMe
Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs in presence of bovine alkaline phosphatase by clonogenic assay
Cytotoxicity against human Ramos cells assessed as cell survival after 72 hrs in presence of bovine alkaline phosphatase by clonogenic assay
[PMID: 22148292]
体外研究
(In Vitro)

The phosphate prodrug may be a suitable choice for ADCs of effector molecules that do not possess sufficient water solubility or stability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DC44SMe 相关抗体:
分子量

806.29

Formula

C38H37ClN5O7PS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DC44SMe 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DC44SMe1354787-76-0ADC CytotoxinADC PayloadPhosphateprodrugcytotoxicDNAalkylatorRamosNamalwaHL60/scancercell targetedtreatmentInhibitorinhibitorinhibit

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产品名称：
DC44SMe
目录号：
HY-135124
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